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      KCI등재 SCOPUS SCIE

      Prenatal Exposure to High Cortisol Induces ADHD-like Behaviors with Delay in Spatial Cognitive Functions during the Post-weaning Period in Rats

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      https://www.riss.kr/link?id=A107292092

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      다국어 초록 (Multilingual Abstract)

      High levels of cortisol in blood are frequently observed in patients with major depressive disorders and increased cortisol level induces depressivelike symptoms in animal models. However, it is still unclear whether maternal cortisol level during pregnancy is a critical factor resulting in neuropsychiatric disorders in offspring. In this study, we increased cortisol level in rats by repetitively injecting corticosterone subcutaneously (Corti.
      Mom, 20 mg/kg/day) during pregnancy and evaluated the behavioral patterns of their pups (Corti.Pups) via forced swimming (FS), open field (OF), elevated plus maze (EPM) and Morris water maze (MWM) tests during the immediate post-weaning period (postnatal day 21 to 25). In results, corticosterone significantly increased plasma cortisol levels in both Corti.Moms and Corti.Pups. Unlike depressive animal models, Corti.Pups showed higher hyperactive behaviors in the FS and OF tests than normal pups (Nor.Pups) born from rats (Nor.Moms) treated with saline. Furthermore, Corti.Pups spent more time and traveled longer distance in the open arms of EPM test, exhibiting higher extremity. These patterns were consistent with behavioral symptoms observed in animal models of attention deficit hyperactivity disorder (ADHD), which is characterized by hyperactivity, impulsivity, and inattention. Additionally, Corti.Pups swam longer and farther to escape in MWM test, showing cognitive declines associated with attention deficit. Our findings provide evidence that maternal cortisol level during pregnancy may affect the neuroendocrine regulation and the brain development of offspring, resulting in heterogeneous developmental brain disorders such as ADHD.
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      High levels of cortisol in blood are frequently observed in patients with major depressive disorders and increased cortisol level induces depressivelike symptoms in animal models. However, it is still unclear whether maternal cortisol level during pre...

      High levels of cortisol in blood are frequently observed in patients with major depressive disorders and increased cortisol level induces depressivelike symptoms in animal models. However, it is still unclear whether maternal cortisol level during pregnancy is a critical factor resulting in neuropsychiatric disorders in offspring. In this study, we increased cortisol level in rats by repetitively injecting corticosterone subcutaneously (Corti.
      Mom, 20 mg/kg/day) during pregnancy and evaluated the behavioral patterns of their pups (Corti.Pups) via forced swimming (FS), open field (OF), elevated plus maze (EPM) and Morris water maze (MWM) tests during the immediate post-weaning period (postnatal day 21 to 25). In results, corticosterone significantly increased plasma cortisol levels in both Corti.Moms and Corti.Pups. Unlike depressive animal models, Corti.Pups showed higher hyperactive behaviors in the FS and OF tests than normal pups (Nor.Pups) born from rats (Nor.Moms) treated with saline. Furthermore, Corti.Pups spent more time and traveled longer distance in the open arms of EPM test, exhibiting higher extremity. These patterns were consistent with behavioral symptoms observed in animal models of attention deficit hyperactivity disorder (ADHD), which is characterized by hyperactivity, impulsivity, and inattention. Additionally, Corti.Pups swam longer and farther to escape in MWM test, showing cognitive declines associated with attention deficit. Our findings provide evidence that maternal cortisol level during pregnancy may affect the neuroendocrine regulation and the brain development of offspring, resulting in heterogeneous developmental brain disorders such as ADHD.

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      참고문헌 (Reference)

      1 Biederman J, "Young adult outcome of attention deficit hyperactivity disorder : a controlled 10-year follow-up study" 36 : 167-179, 2006

      2 Fischer M, "Young adult follow-up of hyperactive children : self-reported psychiatric disorders, comorbidity, and the role of childhood conduct problems and teen CD" 30 : 463-475, 2002

      3 Jichao S, "Saikosaponin A alleviates symptoms of attention deficit hyperactivity disorder through downregulation of DAT and enhancing BDNF expression in spontaneous hypertensive rats" 2017 : 2695903-, 2017

      4 Sobanski E, "Psychiatric comorbidity and functional impairment in a clinically referred sample of adults with attention-deficit/hyperactivity disorder(ADHD)" 257 : 371-377, 2007

      5 Fan JM, "Prenatal stress, anxiety and depression : a mechanism involving CRH peptide family" 35 : 429-439, 2014

      6 Fatima M, "Prenatal stress and depression associated neuronal development in neonates" 60 : 1-7, 2017

      7 Lautarescu A, "Prenatal stress : effects on fetal and child brain development" 150 : 17-40, 2020

      8 Lin YL, "Prenatal lipopolysaccharide exposure increases depression-like behaviors and reduces hippocampal neurogenesis in adult rats" 259 : 24-34, 2014

      9 Iijima M, "Pharmacological characterization of repeated corticosterone injection-induced depression model in rats" 1359 : 75-80, 2010

      10 Soualeh N, "Perinatal programming of depressive-like behavior by inflammation in adult offspring mice whose mothers were fed polluted eels : gender selective effects" 63 : 137-147, 2017

      1 Biederman J, "Young adult outcome of attention deficit hyperactivity disorder : a controlled 10-year follow-up study" 36 : 167-179, 2006

      2 Fischer M, "Young adult follow-up of hyperactive children : self-reported psychiatric disorders, comorbidity, and the role of childhood conduct problems and teen CD" 30 : 463-475, 2002

      3 Jichao S, "Saikosaponin A alleviates symptoms of attention deficit hyperactivity disorder through downregulation of DAT and enhancing BDNF expression in spontaneous hypertensive rats" 2017 : 2695903-, 2017

      4 Sobanski E, "Psychiatric comorbidity and functional impairment in a clinically referred sample of adults with attention-deficit/hyperactivity disorder(ADHD)" 257 : 371-377, 2007

      5 Fan JM, "Prenatal stress, anxiety and depression : a mechanism involving CRH peptide family" 35 : 429-439, 2014

      6 Fatima M, "Prenatal stress and depression associated neuronal development in neonates" 60 : 1-7, 2017

      7 Lautarescu A, "Prenatal stress : effects on fetal and child brain development" 150 : 17-40, 2020

      8 Lin YL, "Prenatal lipopolysaccharide exposure increases depression-like behaviors and reduces hippocampal neurogenesis in adult rats" 259 : 24-34, 2014

      9 Iijima M, "Pharmacological characterization of repeated corticosterone injection-induced depression model in rats" 1359 : 75-80, 2010

      10 Soualeh N, "Perinatal programming of depressive-like behavior by inflammation in adult offspring mice whose mothers were fed polluted eels : gender selective effects" 63 : 137-147, 2017

      11 Bogi E, "Perinatal exposure to venlafaxine leads to lower anxiety and depression-like behavior in the adult rat offspring" 29 : 445-452, 2018

      12 Cox EQ, "Oxytocin and HPA stress axis reactivity in postpartum women" 55 : 164-172, 2015

      13 Eells JB, "Nurr1-null heterozygous mice have reduced mesolimbic and mesocortical dopamine levels and increased stress-induced locomotor activity" 136 : 267-275, 2002

      14 Montarolo F, "NURR1 deficiency is associated to ADHD-like phenotypes in mice" 9 : 207-, 2019

      15 Johnson AC, "Memory impairment in spontaneously hypertensive rats is associated with hippocampal hypoperfusion and hippocampal vascular dysfunction" 40 : 845-859, 2020

      16 Marques AH, "Maternal stress, nutrition and physical activity : impact on immune function, CNS development and psychopathology" 1617 : 28-46, 2015

      17 Slopen N, "Maternal experiences of intimate partner violence and Creactive protein levels in young children in Tanzania" 6 : 107-115, 2018

      18 Raz L, "MMP-9 inhibitors impair learning in spontaneously hypertensive rats" 13 : e0208357-, 2018

      19 Bairos-Novak KR, "Like mother, like daughter : heritability of female Richardson's ground squirrel Urocitellus richardsonii cortisol stress responses" 64 : 153-163, 2018

      20 Keresztes A, "Hair cortisol concentrations are associated with hippocampal subregional volumes in children" 10 : 4865-, 2020

      21 Huang D, "Forebrain excitatory neuron-specific SENP2 knockout mouse displays hyperactivity, impaired learning and memory, and anxiolyticlike behavior" 13 : 59-, 2020

      22 Salari AA, "Fluoxetine normalizes the effects of prenatal maternal stress on depression-and anxiety-like behaviors in mouse dams and male offspring" 311 : 354-367, 2016

      23 Gong Y, "Female early adult depression results in detrimental impacts on the behavioral performance and brain development in offspring" 18 : 461-470, 2012

      24 Swales DA, "Exposure to traumatic events in childhood predicts cortisol production among high risk pregnant women" 139 : 186-192, 2018

      25 Sandman CA, "Exposure to prenatal psychobiological stress exerts programming influences on the mother and her fetus" 95 : 7-21, 2012

      26 Mateos RM, "Excess hydrocortisone hampers placental nutrient uptake disrupting cellular metabolism" 2018 : 5106174-, 2018

      27 Braithwaite EC, "Effects of prenatal depressive symptoms on maternal and infant cortisol reactivity" 19 : 581-590, 2016

      28 Gáll Z, "Effects of chronic cannabidiol treatment in the rat chronic unpredictable mild stress model of depression" 10 : 801-, 2020

      29 Takai Y, "Early-life photoperiod influences depression-like behavior, prepulse inhibition of the acoustic startle response, and hippocampal astrogenesis in mice" 374 : 133-143, 2018

      30 Tassan Mazzocco M, "Dysfunction of the serotonergic system in the brain of synapsin triple knockout mice is associated with behavioral abnormalities resembling synapsinrelated human pathologies" 105 : 110135-, 2021

      31 Doolin K, "Diurnal hypothalamic-pituitary-adrenal axis measures and inflammatory marker correlates in major depressive disorder" 18 : 2226-, 2017

      32 Tibu F, "Disruptions of working memory and inhibition mediate the association between exposure to institutionalization and symptoms of attention deficit hyperactivity disorder" 46 : 529-541, 2016

      33 Li J, "Differential behavioral and neurobiological effects of chronic corticosterone treatment in adolescent and adult rats" 10 : 25-, 2017

      34 Kozłowska A, "Differences in serum steroid hormones concentrations in spontaneously hypertensive rats(SHR)-an animal model of attention-deficit/hyperactivity disorder(ADHD)" 68 : 25-36, 2019

      35 Dwivedi Y, "Chronic corticosterone-mediated dysregulation of microRNA network in prefrontal cortex of rats : relevance to depression pathophysiology" 5 : e682-, 2015

      36 Grünblatt E, "Characterization of cognitive deficits in spontaneously hypertensive rats, accompanied by brain insulin receptor dysfunction" 3 : 6-, 2015

      37 Nazzari S, "Beyond the HPA-axis : exploring maternal prenatal influences on birth outcomes and stress reactivity" 101 : 253-262, 2019

      38 Sagvolden T, "Behavioral validation of the spontaneously hypertensive rat(SHR)as an animal model of attentiondeficit/hyperactivity disorder(AD/HD)" 24 : 31-39, 2000

      39 Pfiffner LJ, "Behavior management for school-aged children with ADHD" 23 : 731-746, 2014

      40 Alenko A, "Association of serum cortisol level with severity of depression and improvement in newly diagnosed patients with major depressive disorder in Jimma medical center, Southwest Ethiopia" 15 : e0240668-, 2020

      41 Kong H, "Aquaporin-4 knockout exacerbates corticosteroneinduced depression by inhibiting astrocyte function and hippocampal neurogenesis" 20 : 391-402, 2014

      42 Bagosi Z, "Anxiolytic-and antidepressant-like actions of Urocortin 2 and its fragments in mice" 1680 : 62-68, 2018

      43 Abdul Aziz NU, "Antidepressantlike properties of fish oil on postpartum depression-like rats model : involvement of serotonergic system" 10 : 733-, 2020

      44 Nestler EJ, "Animal models of neuropsychiatric disorders" 13 : 1161-1169, 2010

      45 Lee B, "Angelica gigas ameliorate depression-like symptoms in rats following chronic corticosterone injection" 15 : 210-, 2015

      46 Rojas P, "Adult mice with reduced Nurr1 expression : an animal model for schizophrenia" 12 : 756-766, 2007

      47 Marceau K, "A systematic review of hair cortisol during pregnancy : reference ranges and methodological considerations" 122 : 104904-, 2020

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2015-01-01 평가 등재학술지 선정 (계속평가) KCI등재
      2013-01-01 평가 등재후보 1차 FAIL (등재후보1차) KCI등재후보
      2012-01-01 평가 등재후보학술지 유지 (기타) KCI등재후보
      2010-01-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.25 0.25 0.22
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.2 0.19 0.459 0.05
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