Antigen targeting to M cells for enhancing the efficacy of mucosal vaccines

다국어 초록 (Multilingual Abstract)

Vaccination is one of the most successful applications of immunology and for a long time has depended on parenteral administration protocols. However, recent studies have pointed to the promise of mucosal vaccination because of its ease, economy and efficiency in inducing an immune response not only systemically, but also in the mucosal compartment where many pathogenic infections are initiated. However, successful mucosal vaccination requires the help of an adjuvant for the efficient delivery of vaccine material into the mucosa and the breaking of the tolerogenic environment, especially in oral mucosal immunization. Given that M cells are the main gateway to take up luminal antigens and initiate antigen-specificimmune responses, understanding the role and characteristics of M cells is crucial for the development of successful mucosal vaccines. Especially, particular interest has been focused on the regulation of the tolerogenic mucosal microenvironment and the introduction of the luminal antigen into the lymphoid organ by exploiting the molecules of M cells. Here, we review the characteristics of M cells and the immune regulatory factors in mucosa that can be exploited for mucosal vaccine delivery and mucosal immune regulation.

참고문헌 (Reference)

1 Curran RM, "Vaginal delivery of the recombinant HIV-1 clade-C trimeric gp140 envelope protein CN54gp140 within novel rheologically structured vehicles elicits specific immune responses" 27 : 6791-6798, 2009

2 Holmgren J, "Vaccines against mucosal infections" 24 : 343-353, 2012

3 Coffman RL, "Vaccine adjuvants : putting innate immunity to work" 33 : 492-503, 2010

4 Chen K, "Vaccination strategies to promote mucosal antibody responses" 33 : 479-491, 2010

5 Anh DD, "Use of oral cholera vaccines in an outbreak in Vietnam: a case control study" 5 : e1006-, 2011

6 Hase K, "Uptake through glycoprotein 2 of FimH(þ)bacteria by M cells initiates mucosal immune response" 462 : 226-230, 2009

7 Foster N, "Ulex europaeus 1 lectin targets microspheres to mouse Peyer’s patch M-cells in vivo" 16 : 536-541, 1998

8 Fraser A, "Typhoid fever vaccines : systematic review and meta-analysis of randomised controlled trials" 25 : 7848-7857, 2007

9 Sato S, "Transcription factor Spi-B-dependent and-independent pathways for the development of Peyer’s patch M cells" 6 : 838-846, 2013

10 Strugnell RA, "The role of secretory antibodies in infection immunity" 8 : 656-667, 2010

11 Clevers H, "The intestinal crypt, a prototype stem cell compartment" 154 : 274-284, 2013

12 Crump JA, "The global burden of typhoid fever" 82 : 346-353, 2004

13 Gregorieff A, "The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium" 137 : 1333-1345, 2009

14 Kim SH, "The M cell-targeting ligand promotes antigen delivery and induces antigen-specific immune responses in mucosal vaccination" 185 : 5787-5795, 2010

15 Kanaya T, "The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells" 13 : 729-736, 2012

16 Brandtzaeg P, "Terminology : nomenclature of mucosa-associated lymphoid tissue" 1 : 31-37, 2008

17 Hervouet C, "Sublingual immunization with an HIV subunit vaccine induces antibodies and cytotoxic T cells in the mouse female genital tract" 28 : 5582-5590, 2010

18 van der Flier LG, "Stem cells, self-renewal, and differentiation in the intestinal epithelium" 71 : 241-260, 2009

19 Sato T, "Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche" 459 : 262-265, 2009

20 Tahoun A, "Salmonella transforms follicle-associated epithelial cells into M cells to promote intestinal invasion" 12 : 645-656, 2012

21 Greenberg HB, "Rotaviruses : from pathogenesis to vaccination" 136 : 1939-1951, 2009

22 Uematsu S, "Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5" 9 : 769-776, 2008

23 Avalos AM, "Regulation of autoreactive B cell responses to endogenous TLR ligands" 43 : 76-83, 2010

24 Lycke N, "Recent progress in mucosal vaccine development : potential and limitations" 12 : 592-605, 2012

25 Peltola H, "Prevention of travellers’ diarrhoea by oral B-subunit/whole-cell cholera vaccine" 338 : 1285-1289, 1991

26 de Lau W, "Peyer’s patch M cells derived from Lgr5(þ)stem cells require SpiB and are induced by RankL in cultured ‘miniguts’" 32 : 3639-3647, 2012

27 Pabst O, "Oral tolerance to food protein" 5 : 232-239, 2012

28 Tsuji NM, "Oral tolerance : intestinal homeostasis and antigenspecific regulatory T cells" 29 : 532-540, 2008

29 Mestecky J, "Oral immunization : an update" 24 : 713-719, 2008

30 Quiding M, "Oral cholera vaccination induces strong intestinal antibody responses and interferon-gamma production and evokes local immunological memory" 88 : 143-148, 1991

31 Hoft DF, "Optimizing vaccine development" 13 : 934-942, 2011

32 Hirabayashi J, "Oligosaccharide specificity of galectins : a search by frontal affinity chromatography" 1572 : 232-254, 2002

33 Clemens J, "New-generation vaccines against cholera" 8 : 701-710, 2011

34 Pavot V, "New insights in mucosal vaccine development" 30 : 142-154, 2012

35 Pabst O, "New concepts in the generation and functions of IgA" 12 : 821-832, 2012

36 Nakato G, "New approach for m-cell-specific molecules screening by comprehensive transcriptome analysis" 16 : 227-235, 2009

37 Neutra MR, "Mucosal vaccines : the promise and the challenge" 6 : 148-158, 2006

38 McGowin CL, "Mucosal treatments for herpes simplex virus : insights on targeted immunoprophylaxis and therapy" 5 : 15-22, 2010

39 Holmgren J, "Mucosal immunity and vaccines" 11 : S45-S53, 2005

40 Tengvall S, "Mucosal administration of CpG oligodeoxynucleotide elicits strong CC and CXC chemokine responses in the vagina and serves as a potent Th1-tilting adjuvant for recombinant gD2 protein vaccination against genital herpes" 80 : 5283-5291, 2006

41 김새해, "Mucosal Immune System and M Cell-targeting Strategies for Oral Mucosal Vaccination" 대한면역학회 12 (12): 165-175, 2012

42 Osanai A, "Mouse peptidoglycan recognition protein PGLYRP-1 plays a role in the host innate immune response against Listeria monocytogenes infection" 79 : 858-866, 2011

43 Manicassamy S, "Modulation of adaptive immunity with Tolllike receptors" 21 : 185-193, 2009

44 Mabbott NA, "Microfold(M)cells : important immunosurveillance posts in the intestinal epithelium" 6 : 666-677, 2013

45 Tyrer P, "Microbial pattern recognition receptors mediate M-cell uptake of a gram-negative bacterium" 74 : 625-631, 2006

46 Corr SC, "M-cells: origin, morphology and role in mucosal immunity and microbial pathogenesis" 52 : 2-12, 2008

47 Clark MA, "M-cell surface beta1 integrin expression and invasin-mediated targeting of Yersinia pseudotuberculosis to mouse Peyer’s patch M cells" 66 : 1237-1243, 1998

48 Kim SH, "M cells expressing the complement C5a receptor are efficient targets for mucosal vaccine delivery" 41 : 3219-3229, 2011

49 Kuolee R, "M cell-targeted delivery of vaccines and therapeutics" 5 : 693-702, 2008

50 Lo DD, "M cell targeting by a Claudin 4 targeting peptide can enhance mucosal IgA responses" 12 : 7-, 2012

51 Nesburn AB, "Local periocular vaccination protects against eye disease more effectively than systemic vaccination following primary ocular herpes simplex virus infection in rabbits" 72 : 7715-7721, 1998

52 Carter NJ, "Live attenuated influenza vaccine(FluMist(R);Fluenz) : a review of its use in the prevention of seasonal influenza in children and adults" 71 : 1591-1622, 2011

53 Christensen D, "Liposome-based cationic adjuvant formulations (CAF): past, present, and future" 19 : 2-11, 2009

54 Hsieh EH, "Jagged1 and Notch1 help edit M cell patterning in Peyer’s patch follicle epithelium" 37 : 306-312, 2012

55 Shafique M, "Induction of mucosal and systemic immunity against respiratory syncytial virus by inactivated virus supplemented with TLR9 and NOD2 ligands" 30 : 597-606, 2012

56 Bemark M, "Induction of gut IgA production through T cell-dependent and T cell-independent pathways" 1247 : 97-116, 2012

57 Mitragotri S, "Immunization without needles" 5 : 905-916, 2005

58 Barker N, "Identification of stem cells in small intestine and colon by marker gene Lgr5" 449 : 1003-1007, 2007

59 Kobayashi A, "Identification of novel genes selectively expressed in the follicle-associated epithelium from the meta-analysis of transcriptomics data from multiple mouse cell and tissue populations" 19 : 407-422, 2012

60 Keely S, "Hypoxia-inducible factor-dependent regulation of platelet-activating factor receptor as a route for gram-positive bacterial translocation across epithelia" 21 : 538-546, 2010

61 Kunisawa J, "Gut-associated lymphoid tissues for the development of oral vaccines" 64 : 523-530, 2012

62 Agren LC, "Genetically engineered nontoxic vaccine adjuvant that combines B cell targeting with immunomodulation by cholera toxin A1 subunit" 158 : 3936-3946, 1997

63 Kyd JM, "Functional differences between M cells and enterocytes in sampling luminal antigens" 26 : 6221-6224, 2008

64 Mutreja A, "Evidence for several waves of global transmission in the seventh cholera pandemic" 477 : 462-465, 2011

65 Smith DJ, "Evaluation of novel aerosol formulations designed for mucosal vaccination against influenza virus" 21 : 2805-2812, 2003

66 Kirkpatrick BD, "Evaluation of Salmonella enterica serovar Typhi (Ty2 aroC-ssaV-)M01ZH09, with a defined mutation in the Salmonella pathogenicity island 2, as a live, oral typhoid vaccine in human volunteers" 24 : 116-123, 2006

67 Owen RL, "Epithelial cell specialization within human Peyer’s patches : an ultrastructural study of intestinal lymphoid follicles" 66 : 189-203, 1974

68 Neutra MR, "Epithelial M cells : gateways for mucosal infection and immunization" 86 : 345-348, 1996

69 Azizi A, "Enhancing oral vaccine potency by targeting intestinal M cells" 6 : e1001147-, 2010

70 Madhi SA, "Effect of human rotavirus vaccine on severe diarrhea in African infants" 362 : 289-298, 2010

71 Clark MA, "Differential surface characteristics of M cells from mouse intestinal Peyer’s and caecal patches" 26 : 271-280, 1994

72 Kozlowski PA, "Differential induction of mucosal and systemic antibody responses in women after nasal, rectal, or vaginal immunization: influence of the menstrual cycle" 169 : 566-574, 2002

73 Mach J, "Development of intestinal M cells" 206 : 177-189, 2005

74 Wolf JL, "Determinants of reovirus interaction with the intestinal M cells and absorptive cells of murine intestine" 85 : 291-300, 1983

75 Nakato G, "Cutting Edge : Brucella abortus exploits a cellular prion protein on intestinal M cells as an invasive receptor" 189 : 1540-1544, 2012

76 Kerneis S, "Conversion by Peyer’s patch lymphocytes of human enterocytes into M cells that transport bacteria" 277 : 949-952, 1997

77 Kozlowski PA, "Comparison of the oral, rectal, and vaginal immunization routes for induction of antibodies in rectal and genital tract secretions of women" 65 : 1387-1394, 1997

78 Ferreccio C, "Comparative efficacy of two, three, or four doses of TY21a live oral typhoid vaccine in entericcoated capsules: a field trial in an endemic area" 159 : 766-769, 1989

79 Schulz O, "Antigen sampling in the small intestine" 34 : 155-161, 2013

80 Rand JH, "Annexin A5binds to lipopolysaccharide and reduces its endotoxin activity" 3 : e00292-, 2012

81 Sebert P, "A simple device for measuring a vertical jump : description and results" 61 : 271-273, 1990

82 Eliasson DG, "A novel non-toxic combined CTA1-DD and ISCOMS adjuvant vector for effective mucosal immunization against influenza virus" 29 : 3951-3961, 2011

83 Nochi T, "A novel M cell-specific carbohydrate-targeted mucosal vaccine effectively induces antigen-specific immune responses" 204 : 2789-2796, 2007

84 Tate JE, "2008 estimate of worldwide rotavirus-associated mortality in children younger than 5 years before the introduction of universal rotavirus vaccination programmes : a systematic review and meta-analysis" 12 : 136-141, 2012