알레르기성 비염환자에 있어서의 Methacholine 검사에 관한 연구 = 알레르기성 비염환자에 있어서의 Methacholine 검사에 관한 연구

다국어 초록 (Multilingual Abstract)

We studied methacholine challenge response in 29 patients with allergic rhinitis. Fourteen wer males and 15 females with ages from 16 to 52(mea n 32. 5) years. The perennial symptom was noted I n 14 and season a l symptom I n 3. The symptom ur st ion was less than 1 year in 12, 1 to 5 years in I and more than 5 years in 5. Using CPI 5, 000 II Pulmol ab System, the FEV, and FEF:, were measured 5 minutes after 5 inh a lations cf saline and methacholine solution(25mg/ml) with nebulizer Devilbiss No. 14 after initi al baseline Pulmonary function tests. The challenges of methacholi ae were repeated 4 times more (Total 25 inhalatio ns) in maximum except for the patiente resulting severe respiratory distress. The results obt aine d were as follow: The patient s of methacholine response(% fall of FEV,>15 %) could be divided into 4 gro ups. (Fig. 2) a) Group I (9 pstients): No response b) Group II (10 paitents): Response to large does (20 - 25 inhalations) c) Group g ( 5 pstients): Response to medium dose (5- 1 5 inhalations) with plsteau slope on further challenges. D) Group III (5 patients): Response to small dose with severe pulmonary distress on further challenges 2. In genersl the % fall of FEF,In methacholine challenge was more marked than that of FEV,. The 7 fall of FEF In Group II was earlier and more marked than that of FEV,. (Fig. 3) 3 , There was not significant difference in the age of onset, symptom dur ation, total eosinophil counts, serum IgE(PRIST) and the findi ngs af sputum eosin ephils between groups. 4. Response to rnethacholine challenge was more significantly remarkable in pati ents with chest symptoms. All patients I n Group IV had dyspnea cf some degree but none in Group I.