α-Amyrin Triterpenoids and Two Known Compounds with DNA Topoisomerase IInhibitory Activity and Cytotoxicity from the Spikesof Prunella vulgaris var. lilacina

다국어 초록 (Multilingual Abstract)

known α-amyrin triterpenoids, ursolic acid (1), 2α,3α-dihydro xyurs-12-ene-28-oic acid (2) andeuscaphic acid (3), and β-amyrin triterpenoid, 3β-hydroxyolean-5,12-diene (4), and α-spinasterol (5) have beenisolated from the fractionated n-butanol extracts of the spikes of Prunella vulgaris var. lilacina, guided by DNAtopoisomerases I and II inhibitory activities and cytotoxic activity against human cancer cells. Their structureswere elucidated on the basis of spectroscopic and chemical methods. Compound 4 exhibited significant cytotoxicactivity against human colon adenoblastoma (HT-29), and 5 showed DNA topoisomerase I and II inhibitions.Key words - Prunella vulgaris var. lilacina, DNA topoisomerases I and II inhibitory activities, cytotoxic activity,ursolic acid, 2α,3α-dihydroxyurs-12-ene-28-oic acid, euscaphic acid

참고문헌 (Reference)

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