Transfer of Immunity to Clonorchis sinensis Infection by Peritoneal Cells, Spleen Cells and Sera in BALB/C Mice = BALB/c 마우스에서 腹腔 및 脾臟細胞와 血淸의 肝吸蟲에 對한 免疫移入

국문 초록 (Abstract)

肝吸蟲 成蟲의 代謝産物과 蟲體構成物의 footpad內 注射로 感作한 BALB/c마우스의 腹腔細胞와 血淸 또는 脾臟細胞와 血淸을 同系 recipient 마우스의 腹腔 內에 注入하였을 때 肝吸蟲 成蟲에 對한 免疫이 移入되는지 그 與否를 對照群 마우스의 EpG, Worm burden, 脾臟 當 Plaque 形成細胞의 數를 基準으로하여 感作群에서의 그 成績과 比較하였다.
Challenge 感作 後, EpG는 對照群에서 感作群에 比하여 일찍, 많이 나타났으며 肝吸蟲 成蟲의 回收率에서는 對照群과 感作群 사이에 有意的인 差異를 認定할 수 있었다.
脾臟에서 Plaque 形成細胞는 對照群 마우스에서 檢出되지 않았으나, 感作群에서는 相當數 檢出되었다.

다국어 초록 (Multilingual Abstract)

The effect of peritonal cells (PC) and sera and/or spleen cells (SC) and sera of BALB/c mice on tansfer of immunity against Clonorchis sinensis(C. sinensis) to the syngeneic recipient mice was studied.
Group Ⅰ of donor mice were sensitized by injecting the admixture of the metabolic products, and Group Ⅱ by the somatic constituents, of C. sinensis and Freund's incomplete adjuvant into footpads twice at 2 weeks' interval.
After challenge infection with metacercariae of C. sinensis, the eggs of control groups appeared earlier and much more numerously than those of recipient groups.
There was a significant difference in worm burdens between one of the recipient and control groups.
There were a small number of plaque forming cells(PFC) in all sensitized groups, but no PFC in the control mice.
It was found that PC and sera of BALB/c mice are able to transfer immunity against C. sinensis to syngeneic recipients.