Control of neuronal migratory through rostral migration stream in mice

다국어 초록 (Multilingual Abstract)

During the nervous system development, immature neuroblasts have a strong potential to migrate toward their destination. In the adult brain, new neurons are continuously generated in the neurogenic niche located near the ventricle, and the newly generated cells actively migrate toward their destination, olfactory bulb, via highly specialized migratory route called rostral migratory stream (RMS). Neuroblasts in the RMS form chains by their homophilic interactions, and the neuroblasts in chains continually migrate through the tunnels formed by meshwork of astrocytes, glial tube. This review focuses on the development and structure of RMS and the regulation of neuroblast migration in the RMS. Better understanding of RMS migration may be crucial for improving functional replacement therapy by supplying endogenous neuronal cells to the injury sites more efficiently.

목차 (Table of Contents)

• Introduction
• Development and Structure of RMS
• Factors Regulating RMS Migration
• The Fate of Migrated Neuroblasts in the OB
• Conclusion and Perspective