명아주 에탄올 추출물의 TNF-α, IL-1α 생성 억제와 TNF-α, IL-1α mRNA 발현 억제 효과 = Inhibition Effect of TNF-α, IL-1α Production and TNF-α, IL-1α mRNA Expression from Chenopodium album Ethanol Extract

다국어 초록 (Multilingual Abstract)

In this study, anti-oxidant and anti-inflammatory effect of Chenopodium album var. centrorubrum (C. album) were investigated in order to observe the usability as a natural cosmetics material. C. album ethanol extract was tested for i) free radical scavenging activity, ii) production inhibition of TNF-a and IL-1a in RAW 264.7 cell, and iii) inhibition of TNF-α and IL-1α mRNA expression in HaCaT cell. C. album ethanol extract resulted scavenging effect of DPPH(39.7 ± 2.1%) and SO(33.7 ± 2.3%) at 10 ppm. Production inhibition of TNF-α and IL- 1α was significantly higher than the LPS-untreated cells, but significantly lower than only LPS-treated cells(p<0.001). mRNA expression of TNF-α(35.2 ± 2.2%) and IL-1α(2.8 ± 0.3%) was significantly lower than positive control d-panthenol(52.6 ± 3.1%, 55.9 ± 2.0%) in HaCaT cells. In conclusion, C. album may be applicable as a new natural materials for aging skin, oily skin, and acne skin.

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