사람의 편도선 림프구에서의 INterleulcin 4에 의한 저친화성 IgE 수용체 및 Interleukin 4 수용체의 발현조절에 관한 연구 = 사람의 편도선 림프구에서의 INterleulcin 4에 의한 저친화성 IgE 수용체 및 Interleukin 4 수용체의 발현조절에 관한 연구

다국어 초록 (Multilingual Abstract)

Human interleukin 4 (IL-4) is a T cell- produced lymphokine with diverse biologic activities, IL-4 has pronounced effects on preactiviated B lymphocytes where it induce IgE secretion. The low affinity IgE Fc receptor (Fc II /CD23) stage specific marker and has been thought to play an important role in IgE regulation by IL-4. In this study, we investigated the express- ion of CD23 and IL-4 receptor (IL-4R) expression induced by IL-4 on human tonsillar lymphocytes using flow cytometry. The results are as follows 1) IL-4 upregulated CD23 and IL-4R expression on resting B cells in a dose-dependent manner. 2) IL-4 increased the cell size without significant increase in DNA synthesis. Most enlarged cells showed increased expression of both of CD23 and IL-4R. 3) IFN- 1 inhibited both CD23 and IL-4R expression induced by CD23, expression. 4) On T cells, IL-4 did not increase IL-4R or CD23 whereas activation with PHA induced increase in DNA synthesis and IL-4R expression. These results indicate that IL-4 regulates the expression CD23 and IL-4R in different manner depending on the cell types, Futher studies on m-RNA transcription of these molecules are needed so as to elucidate the mechanisms of modulation.