급성 (急性) 바이러스성 간염에서 (肝炎) 혈청 (血淸 ) HBsAg / IgM 결합체의 (結合體) 임상적 (臨床的) 의의 = The Clinical Significance of Circulating HBsAg / IgM Complexes in BBv Hepatitis급성 (急性) 바이러스성 간염에서 (肝炎) 혈청 (血淸 ) HBsAg / IgM 결합체의 (結合體) 임상적 (臨床的) 의의

다국어 초록 (Multilingual Abstract)

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다국어 초록 (Multilingual Abstract)

Circulating immune complexes are frequently found in the blood of patients with acute or chronic hepatitis type B. Recently, Palla and coworkers reported the apparent presence of HBsAg/IgMspecific anti-HBs complexes in acute and chronic hepatitis B and indicated that the presence of these immune complexes may function as prognostic indicators of chronic evolution. Therefore, we observed for the detection of HBsAg/IgM complexes and studied the significance of their presence in acute and chronic type B hepatitis. A total of 155 HBsAg-positive patients were carried out for this study from Mar, 1980 to Feb. 1986 in this hospital. They were included as 28 patients with asymptomatic hepatitis B carriers, 77 patients with acute hepatitis B, and 50 patients with chronic hepatitis B, respectively. The following results in this study were obtained: 1) Circulating HBsAg/IgM complexes were found in 15 out of 28 (54%) asymptomatic hepatitis B carriers, in 26 out of 77 (34%) acute hepatitis B patients, and in 26 out of 50 (52%) chronic hepatitis B patients, respectively. 2) Circulating HBsAg/IgM Complexes in patients with acute B hepatitis were either absent from the initial hospital day or disappeared from four weeks hospitalization, and recovered clinically within two months. 3) The acute hepatitis B patients, being detectable circulating HBsAg/IgM complexes, had persistent elevation of serum alanine transaminase at least six months period. It is suggested that circulating HBsAg/IgM complexes seem to be of important prognostic and diagnostic value in acute and chronic hepatitis B.