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      생맥산(生脈散)의 방사선 보호효과 : 생쥐 소낭세포 재생과 Apoptosis에 미치는 영향 = Radioprotective Effect of Saengmaek-san on Mice Jejunal Crypt Cell Survival and Apoptosis

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      https://www.riss.kr/link?id=A100743248

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      다국어 초록 (Multilingual Abstract)

      Backgrounds & Objects: The aim of this study was to investigate the radioprotective effect of Shengmai-san(SMS), a herbal medicine, on mice jejunal crypt cell survival and Apoptosis. Methods: Mice were devided into 4 groups according to radiation dose and SMS treatment: Normal was the group without irradiation. Control was the group treated with D.W before 10 Gy irradiation. SMS 2.9 was sample group treated with 2.9 mg/10 g of SMS extract before 10 Gy irradiation and SMS 29 was sample group treated with 29 mg/10 g of SMS extract before 10 Gy irradiation. And Each group were sacrificedat 24 hours and 72 hours after irradiation. To analyze the crypt survival, hematoxylin-eosin staining was used and to analyze the apoptosis, the TUNEL assay was done. Results: 1. From the microcolony survival assay, the SMS 2.9 and SMS 29 showed the radioprotective effect with a statistical significance compared to the control group at 24 hr (P < 0.01) and 72 hr (p < 0.001) after 10 Gy irradiatien. And the differences of radioprotective effect between SMS 2.9 and SMS 29 were net significant. 2. The results of the TUNEL assay showed that the apoptotic index in SMS 2.9 and SMS 29 was significantly decreased, as compared to the control group at both 24 hr ( p < 0.01) and 72 hr (SMS 2.9 : p < 0.001. SMS 29 : P < 0.01) after 10Gy irradiation And the differences of between SMS 2.9 and SMS 29 were not significant. Conclusions: It could be suggested that the Shengmai-san has a prominent Protective effect in mice intestines against the radiation damage. And the radieprotective effect seems to be related to inhibition of the apoptosis.
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      Backgrounds & Objects: The aim of this study was to investigate the radioprotective effect of Shengmai-san(SMS), a herbal medicine, on mice jejunal crypt cell survival and Apoptosis. Methods: Mice were devided into 4 groups according to radiation dose...

      Backgrounds & Objects: The aim of this study was to investigate the radioprotective effect of Shengmai-san(SMS), a herbal medicine, on mice jejunal crypt cell survival and Apoptosis. Methods: Mice were devided into 4 groups according to radiation dose and SMS treatment: Normal was the group without irradiation. Control was the group treated with D.W before 10 Gy irradiation. SMS 2.9 was sample group treated with 2.9 mg/10 g of SMS extract before 10 Gy irradiation and SMS 29 was sample group treated with 29 mg/10 g of SMS extract before 10 Gy irradiation. And Each group were sacrificedat 24 hours and 72 hours after irradiation. To analyze the crypt survival, hematoxylin-eosin staining was used and to analyze the apoptosis, the TUNEL assay was done. Results: 1. From the microcolony survival assay, the SMS 2.9 and SMS 29 showed the radioprotective effect with a statistical significance compared to the control group at 24 hr (P < 0.01) and 72 hr (p < 0.001) after 10 Gy irradiatien. And the differences of radioprotective effect between SMS 2.9 and SMS 29 were net significant. 2. The results of the TUNEL assay showed that the apoptotic index in SMS 2.9 and SMS 29 was significantly decreased, as compared to the control group at both 24 hr ( p < 0.01) and 72 hr (SMS 2.9 : p < 0.001. SMS 29 : P < 0.01) after 10Gy irradiation And the differences of between SMS 2.9 and SMS 29 were not significant. Conclusions: It could be suggested that the Shengmai-san has a prominent Protective effect in mice intestines against the radiation damage. And the radieprotective effect seems to be related to inhibition of the apoptosis.

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      참고문헌 (Reference)

      1 "암의 치법,치방 및 치료약물에 관한 문헌적 고찰" 6 (6): 161-166, 1986

      2 "생쥐에서 과립구 집락형성인자(Granulocyte Colony Stimulating Factor)의 공장점막에 대한 방사선 보호효과" 19 (19): 45-50, 2001

      3 "방사선치료학" 대학서림 32-33, 1998

      4 "방사선 조사 후의 N:GPS mouse 비장세포 증식에 미치는 補中益氣湯과 四六湯의 효과" 110-239, 1995

      5 "멜라토닌이 생쥐 소낭 세포 재생과 아포토시스에 미치는 영향에 대한 연구" 18 (18): 60-67, 2000

      6 "국내 병원 별 방사선 치료의 진료구조 현황" 17 (17): 172-178, 1999

      7 "扶正生津湯이 방사선 조사 부작용에 미치는 영향" 19 (19): 125-138, 1998

      8 "加味香砂六君子湯이 생쥐 소장에서 방사선 조사 후 보호효과와 Apoptosis에 미치는 영향" 6 (6): 1-18, 2000

      9 "加味沙蔘麥門冬湯이 항암활성과 방사선부작용 억제효과에 미치는 영향" 대전대학교한의학연구소 8 (8): 403-424, 1999

      10 "The global burden of disease 2000 project aims methods and data sources" 2001

      1 "암의 치법,치방 및 치료약물에 관한 문헌적 고찰" 6 (6): 161-166, 1986

      2 "생쥐에서 과립구 집락형성인자(Granulocyte Colony Stimulating Factor)의 공장점막에 대한 방사선 보호효과" 19 (19): 45-50, 2001

      3 "방사선치료학" 대학서림 32-33, 1998

      4 "방사선 조사 후의 N:GPS mouse 비장세포 증식에 미치는 補中益氣湯과 四六湯의 효과" 110-239, 1995

      5 "멜라토닌이 생쥐 소낭 세포 재생과 아포토시스에 미치는 영향에 대한 연구" 18 (18): 60-67, 2000

      6 "국내 병원 별 방사선 치료의 진료구조 현황" 17 (17): 172-178, 1999

      7 "扶正生津湯이 방사선 조사 부작용에 미치는 영향" 19 (19): 125-138, 1998

      8 "加味香砂六君子湯이 생쥐 소장에서 방사선 조사 후 보호효과와 Apoptosis에 미치는 영향" 6 (6): 1-18, 2000

      9 "加味沙蔘麥門冬湯이 항암활성과 방사선부작용 억제효과에 미치는 영향" 대전대학교한의학연구소 8 (8): 403-424, 1999

      10 "The global burden of disease 2000 project aims methods and data sources" 2001

      11 "The effect of overall treatment time on local control in patients with adenocarcinoma of the prostate treated with radiation therapy" 19 (19): 1377-82, 1990

      12 "Role of component herbs in antioxidant activity of shengmai san a traditional chinese medicine formula preventing cerebral oxidative damage in rat" 31 (31): 509-521, 2003

      13 "Recovery of the hematopoietic system by Si Jun Zi Tang in whole body irradiated mice" 54 : 69-75, 1996

      14 "Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy" 62 (62): 255-259, 2005

      15 "Radioprotective potential of ginseng Mutagenesis" 20 (20): 237-243, 2005

      16 "Radioprotective effects of Chinese medical prescriptions in mice" 3 : 164-9, 1986

      17 "Radiobiology for the radiologist" Lippincoff company 1994

      18 "Prevention of oxidative injury in PC12 cells by a traditional chinese medicine Shengmai San as a model of an antioxidant based composite formula" 26 (26): 1000-1004, 2003

      19 "Prevention and repair of cerebral ischemia reperfusion injury by Chinese herbal medicine shengmai san in rats" 31 : 449-455, 1999

      20 "Pathophysiology and therapy of chronic radiation induced injury to the colon" 16 : 253-261, 1998

      21 "In vitro antioxidant potentials of Traditional Chinese Medicine Shengmai San and Their Relation to in Vivo Protective Effect on cerebral Oxidative damage in rats" 25 (25): 898-903, 2002

      22 "Effect of Horminis placenta on radiation induced apoptosis and crypt regeneration in rat small intestine" 경희대학교 대학원 2005

      23 "Chinese herbal medicine shengmai san is effective for improving circulatory shock and oxidative damage in the brain during heatstroke" 97 : 253-265, 2005

      24 "Characterization of radiation- induced apoptosis in the small intestine and its biological implications" 71-8, 1994

      25 "Apoptosis and its role in human disease" 487-793, 1994

      26 "Acute induction of inflammatory cytokine expression after gamma irradiation in the rat effect of an NF kappaB inhibitor" 58 (58): 427-434, 2004

      27 "2004년 사망원인 통계결과 보도자료" 통계청 2005

      28 "2002 Annual report of the Korea Central Cancer Registry Based on Registered Data from 139 hopitals" 36 (36): 103-114, 2004

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2022 평가예정 재인증평가 신청대상 (재인증)
      2019-01-01 평가 등재학술지 유지 (계속평가) KCI등재
      2016-01-01 평가 등재학술지 선정 (계속평가) KCI등재
      2015-12-01 평가 등재후보로 하락 (기타) KCI등재후보
      2011-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2009-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2006-02-09 학술지명변경 외국어명 : THE KOREAN SOCIETY FOR ORIENTAL INTERNAL MEDICINE -> The Journal of Korean Oriental Internal Medicine KCI등재
      2006-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2005-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2003-01-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.67 0.67 0.61
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.56 0.5 0.653 0.03
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