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      KCI등재 SCOPUS

      스테로이드 저항성 신증후군에서 cyclosporine 치료 반응 및 결과 = Therapeutic response of cyclosporine and outcome insteroid resistant nephrotic syndrome

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      https://www.riss.kr/link?id=A104550098

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      다국어 초록 (Multilingual Abstract)

      Purpose:The aim of our study was to evaluate the therapeutic response to cyclosporine, time to remission and side effects in steroid resistant nephrotic syndrome (SRNS).
      Methods:This study included 22 children with idiopathic SRNS who were treated with cyclosporine between June 1989 and August 2006. Medical records were reviewed retrospectively.
      Results:The mean age of patients at diagnosis was 5.2±3.3 years. The male to female ratio was 1.2:1. Pre-treatment renal biopsies showed minimal change (MCD) in 12 (54.5%), focal segmental glomerulosclerosis (FSGS) in 8 (36.4%), membranous nephropathy (MGN) in one (4.5%) and mesangioproliferative glomerulonephritis in one (4.5%). 15 (68.2%) patients responded to cyclosporine, of whom 11 (91.6%) patients were MCD, 3 (37.5%) patients FSGS, and 1 patient MGN (MCD vs FSGS, P<0.05). The time to remission in patients who responded to cyclosporine was 31.5±15.2 days. Four of the 15 cyclosporine responders maintained complete remission even after cessation of the medication Seven still received cyclosporine, 2 were intermittently treated with steroids after discontinuation of cyclosporine, and two were treated with cyclosporine and steroids. The mean duration of cyclosporine therapy was 546.5±346.2, 1,392.9±439.7, 439.5±84.1, and 433.5±74.2 days, respectively. We performed post-treatment biopsies in 8 patients and partial interstitial fibrosis and tubular atrophy were found in two.
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      Purpose:The aim of our study was to evaluate the therapeutic response to cyclosporine, time to remission and side effects in steroid resistant nephrotic syndrome (SRNS). Methods:This study included 22 children with idiopathic SRNS who were treated wit...

      Purpose:The aim of our study was to evaluate the therapeutic response to cyclosporine, time to remission and side effects in steroid resistant nephrotic syndrome (SRNS).
      Methods:This study included 22 children with idiopathic SRNS who were treated with cyclosporine between June 1989 and August 2006. Medical records were reviewed retrospectively.
      Results:The mean age of patients at diagnosis was 5.2±3.3 years. The male to female ratio was 1.2:1. Pre-treatment renal biopsies showed minimal change (MCD) in 12 (54.5%), focal segmental glomerulosclerosis (FSGS) in 8 (36.4%), membranous nephropathy (MGN) in one (4.5%) and mesangioproliferative glomerulonephritis in one (4.5%). 15 (68.2%) patients responded to cyclosporine, of whom 11 (91.6%) patients were MCD, 3 (37.5%) patients FSGS, and 1 patient MGN (MCD vs FSGS, P<0.05). The time to remission in patients who responded to cyclosporine was 31.5±15.2 days. Four of the 15 cyclosporine responders maintained complete remission even after cessation of the medication Seven still received cyclosporine, 2 were intermittently treated with steroids after discontinuation of cyclosporine, and two were treated with cyclosporine and steroids. The mean duration of cyclosporine therapy was 546.5±346.2, 1,392.9±439.7, 439.5±84.1, and 433.5±74.2 days, respectively. We performed post-treatment biopsies in 8 patients and partial interstitial fibrosis and tubular atrophy were found in two.

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      다국어 초록 (Multilingual Abstract)

      Purpose:The aim of our study was to evaluate the therapeutic response to cyclosporine, time to remission and side effects in steroid resistant nephrotic syndrome (SRNS).
      Methods:This study included 22 children with idiopathic SRNS who were treated with cyclosporine between June 1989 and August 2006. Medical records were reviewed retrospectively.
      Results:The mean age of patients at diagnosis was 5.2±3.3 years. The male to female ratio was 1.2:1. Pre-treatment renal biopsies showed minimal change (MCD) in 12 (54.5%), focal segmental glomerulosclerosis (FSGS) in 8 (36.4%), membranous nephropathy (MGN) in one (4.5%) and mesangioproliferative glomerulonephritis in one (4.5%). 15 (68.2%) patients responded to cyclosporine, of whom 11 (91.6%) patients were MCD, 3 (37.5%) patients FSGS, and 1 patient MGN (MCD vs FSGS, P<0.05). The time to remission in patients who responded to cyclosporine was 31.5±15.2 days. Four of the 15 cyclosporine responders maintained complete remission even after cessation of the medication Seven still received cyclosporine, 2 were intermittently treated with steroids after discontinuation of cyclosporine, and two were treated with cyclosporine and steroids. The mean duration of cyclosporine therapy was 546.5±346.2, 1,392.9±439.7, 439.5±84.1, and 433.5±74.2 days, respectively. We performed post-treatment biopsies in 8 patients and partial interstitial fibrosis and tubular atrophy were found in two.
      번역하기

      Purpose:The aim of our study was to evaluate the therapeutic response to cyclosporine, time to remission and side effects in steroid resistant nephrotic syndrome (SRNS). Methods:This study included 22 children with idiopathic SRNS who were treated wi...

      Purpose:The aim of our study was to evaluate the therapeutic response to cyclosporine, time to remission and side effects in steroid resistant nephrotic syndrome (SRNS).
      Methods:This study included 22 children with idiopathic SRNS who were treated with cyclosporine between June 1989 and August 2006. Medical records were reviewed retrospectively.
      Results:The mean age of patients at diagnosis was 5.2±3.3 years. The male to female ratio was 1.2:1. Pre-treatment renal biopsies showed minimal change (MCD) in 12 (54.5%), focal segmental glomerulosclerosis (FSGS) in 8 (36.4%), membranous nephropathy (MGN) in one (4.5%) and mesangioproliferative glomerulonephritis in one (4.5%). 15 (68.2%) patients responded to cyclosporine, of whom 11 (91.6%) patients were MCD, 3 (37.5%) patients FSGS, and 1 patient MGN (MCD vs FSGS, P<0.05). The time to remission in patients who responded to cyclosporine was 31.5±15.2 days. Four of the 15 cyclosporine responders maintained complete remission even after cessation of the medication Seven still received cyclosporine, 2 were intermittently treated with steroids after discontinuation of cyclosporine, and two were treated with cyclosporine and steroids. The mean duration of cyclosporine therapy was 546.5±346.2, 1,392.9±439.7, 439.5±84.1, and 433.5±74.2 days, respectively. We performed post-treatment biopsies in 8 patients and partial interstitial fibrosis and tubular atrophy were found in two.

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      참고문헌 (Reference)

      1 The primary nephrotic syndrome in children, "identification of patients with minimal change nephrotic syndrome frome initial response to prednisone. A report of the International Study of Kidney Disease in Children" 98 : 561-564, 1981

      2 Mendoza SA, "Treatment of steroid-resistant focal segmental glomerulosclerosis with pulse methylprednisolone and alkylating agents" 4 : 303-307, 1990

      3 Frassinetti Castelo Branco Camurca Fernandes P, "Treatment of steroid- resistant nephrotic syndrome with cyclosporine: study of 17 cases and a literature review" 18 : 711-720, 2005

      4 Meyrier A, "Treatment of idiopathic nephrotic syndrome with cyclosporine" 10 : 14-24, 1997

      5 Hamed RM, "Treatment of idiopathic nephrotic syndrome with cyclosporin A in children" 10 : 266-270, 1997

      6 Niaudet P, "Treatment of childhood steroid-resistant idiopathic nephrosis with a combination of cyclosporine and prednisone. French Society of Pediatric Nephrology" 125 : 981-986, 1994

      7 Kim PK, "Therapeutic effect of cyclosporine a on the severe Henoch-Scholein purpura nephritis" 2 : 110-117, 1998

      8 Nammalwar BR, "Steroid resistant nephrotic syndrome is sustained remission attainable" 43 : 39-43, 2006

      9 Geary DF, "Response to cyclophosphamide in steroid-resistant focal segmental glomerulosclerosis: a reappraisal" 22 : 109-113, 1984

      10 Tarshish P, "Prognostic significance of the early course of minimal change nephrotic syndrome: Report of the International Study of Kidney Disease in Children" 8 : 769-776, 1997

      1 The primary nephrotic syndrome in children, "identification of patients with minimal change nephrotic syndrome frome initial response to prednisone. A report of the International Study of Kidney Disease in Children" 98 : 561-564, 1981

      2 Mendoza SA, "Treatment of steroid-resistant focal segmental glomerulosclerosis with pulse methylprednisolone and alkylating agents" 4 : 303-307, 1990

      3 Frassinetti Castelo Branco Camurca Fernandes P, "Treatment of steroid- resistant nephrotic syndrome with cyclosporine: study of 17 cases and a literature review" 18 : 711-720, 2005

      4 Meyrier A, "Treatment of idiopathic nephrotic syndrome with cyclosporine" 10 : 14-24, 1997

      5 Hamed RM, "Treatment of idiopathic nephrotic syndrome with cyclosporin A in children" 10 : 266-270, 1997

      6 Niaudet P, "Treatment of childhood steroid-resistant idiopathic nephrosis with a combination of cyclosporine and prednisone. French Society of Pediatric Nephrology" 125 : 981-986, 1994

      7 Kim PK, "Therapeutic effect of cyclosporine a on the severe Henoch-Scholein purpura nephritis" 2 : 110-117, 1998

      8 Nammalwar BR, "Steroid resistant nephrotic syndrome is sustained remission attainable" 43 : 39-43, 2006

      9 Geary DF, "Response to cyclophosphamide in steroid-resistant focal segmental glomerulosclerosis: a reappraisal" 22 : 109-113, 1984

      10 Tarshish P, "Prognostic significance of the early course of minimal change nephrotic syndrome: Report of the International Study of Kidney Disease in Children" 8 : 769-776, 1997

      11 Schulman SL, "Predicting the response to cytotoxic therapy for childhood nephrotic syndrome: superiority of response to corticosteroid therapy over histopathologic patterns" 113 : 996-1001, 1988

      12 McBryde KD, "Pediatric steroid- resistant nephrotic syndrome" 31 : 280-307, 2001

      13 Snyder SH, "Neural actions of immunophilin ligands" 19 : 21-26, 1998

      14 "Nephrotic syndrome in children: prediction of histopathology from clinical and laboratory characteristics at time of diagnosis" 13 : 159-165, 1978

      15 Choi Y, "Nephrotic syndrome in childhood" 21 : 356-361, 2002

      16 Eddy AA, "Nephrotic syndrome in childhood" 362 : 629-639, 2003

      17 Cameron JS, "Long-term stability of remission in nephrotic syndrome after treatment with cyclophosphamide" 4 : 7-11, 1974

      18 Chiu J, "Long-term follow-up of cyclophosphamide therapy in frequent relapsing minimal lesion nephrotic syndrome" 84 : 825-830, 1974

      19 El-Husseini A, "Long-term effects of cyclosporine in children with idiopathic nephrotic syndrome: a single-centre experience" 20 : 2433-2438, 2005

      20 Hong IH, "Long-term Cyclosporine A(Cypol(R)) therapy in children with idiopathic nephrotic syndrome" 20 : 242-249, 2001

      21 Tune BM, "Intravenous methylprednisolone and oral alkylating agent therapy of prednisone-resistant pediatric focal segmental glomerulosclerosis: a long-term follow-up" 43 : 84-88, 1995

      22 Klintmalm G, "Interstitial fibrosis in renal allografts after 12 to 42 months of cyclosporine treatment: Beneficial effects of low dose in early post transplant period" 2 : 950-954, 1984

      23 Hoyer PF, "Initial treatment of idiopathic nephritic syndrome in children: prednisone versus prednisone plus cyclosporine A: a prospective, randomized trial" 17 : 1151-1157, 2006

      24 Neild GH, "Glomerular thrombi in renal allografts associated with cyclosporine treatment" 38 : 253-258, 1985

      25 Tejani A, "Cyclosporine-induced remission of relapsing nephrotic syndrome in children" 111 : 1056-1062, 1987

      26 Niaudet P, "Cyclosporine in the treatment of idiopathic nephrosis" 5 : 1049-1056, 1994

      27 Niaudet P, "Cyclosporine in the therapy of idiopathic nephrotic syndrome in children. International yearbook of nephrology" Kluwer Academic Publisher 155-168, 1989

      28 Kahan BD, "Cyclosporine" 321 : 1725-1738, 1989

      29 Tarshish P, "Cyclophosphamide dose not benefit patients with focal segmental glomerulosclerosis. A report of the International Study of Kidney Disease in Children" 10 : 590-593, 1996

      30 Ponticelli C, "A randomized trial of cyclosporine in steroid-resistant idiopathic nephrotic syndrome" 43 : 1377-1384, 1993

      31 Lieberman KV, "A randomized double-blind placebo-controlled trial of cyclosporine in steroid-resistant idiopathic focal segmental glomerulosclerosis in children" 7 : 56-63, 1996

      32 Sohn EK, "A clinical trial of cyclosporine A in childhood nephrotic syndrome" 8 : 306-314, 1989

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-15 학술지명변경 한글명 : Korean Journal of Pediatrics -> Clinical and Experimental Pediatrics
      외국어명 : Korean Journal of Pediatrics -> Clinical and Experimental Pediatrics
      KCI등재
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2019-07-16 학회명변경 한글명 : 대한소아과학회 -> 대한소아청소년과학회 KCI등재
      2010-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2009-01-30 학술지명변경 한글명 : 소아과 -> Korean Journal of Pediatrics KCI등재
      2008-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2006-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2003-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2002-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
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      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.18 0.18 0.16
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.17 0.2 0.369 0.06
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