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      Traf4 is required for tight junction complex during mouse blastocyst formation

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      https://www.riss.kr/link?id=A107962391

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      다국어 초록 (Multilingual Abstract)

      Traf4 (Tumor necrosis factor Receptor Associated Factor 4) is a member of the tumor necrosis factor receptor (TNFR) - associated factors (TRAFs) family. TRAF4 is overexpressed in tumor cells such as breast cancer and associated with cytoskeleton and membrane fraction. Interestingly, TRAF4 was localized with tight junctions (TJs) proteins including OCLN and TJP1 in mammary epithelial cells. However, the expression patterns and biological function of Traf4 were not examined in preimplantation mouse embryos although Traf4-deficient mouse showed embryonic lethality or various dramatic malformation. In this study, we examined the temporal and spatial expression patterns of mouse Traf4 during preimplantation development by qRT-PCR and immunostaining, and its biological function by using siRNA injection. We found upregulation of Traf4 from the 8-cell stage onwards and apical region of cell – cell contact sites at morula and blastocyst embryos. Moreover, Traf4 knockdown led to defective TJs without alteration of genes associated with TJ assembly but elevated p21 expression at the KD morula. Taken together, Traf4 is required for TJs assembly and cell proliferation during morula to blastocyst transition.
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      Traf4 (Tumor necrosis factor Receptor Associated Factor 4) is a member of the tumor necrosis factor receptor (TNFR) - associated factors (TRAFs) family. TRAF4 is overexpressed in tumor cells such as breast cancer and associated with cytoskeleton and m...

      Traf4 (Tumor necrosis factor Receptor Associated Factor 4) is a member of the tumor necrosis factor receptor (TNFR) - associated factors (TRAFs) family. TRAF4 is overexpressed in tumor cells such as breast cancer and associated with cytoskeleton and membrane fraction. Interestingly, TRAF4 was localized with tight junctions (TJs) proteins including OCLN and TJP1 in mammary epithelial cells. However, the expression patterns and biological function of Traf4 were not examined in preimplantation mouse embryos although Traf4-deficient mouse showed embryonic lethality or various dramatic malformation. In this study, we examined the temporal and spatial expression patterns of mouse Traf4 during preimplantation development by qRT-PCR and immunostaining, and its biological function by using siRNA injection. We found upregulation of Traf4 from the 8-cell stage onwards and apical region of cell – cell contact sites at morula and blastocyst embryos. Moreover, Traf4 knockdown led to defective TJs without alteration of genes associated with TJ assembly but elevated p21 expression at the KD morula. Taken together, Traf4 is required for TJs assembly and cell proliferation during morula to blastocyst transition.

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      참고문헌 (Reference)

      1 박윤재, "돼지 정소상체에서 ZO-1, Claudin 1 및 Claudin 4의 발현 양상" 사단법인 한국동물생명공학회 34 (34): 190-196, 2019

      2 Rozan LM, "cand characterization of proteins interacting with Traf4, an enigmatic p53target" 5 : 1228-1235, 2006

      3 Kédinger V, "Tumor necrosis factor receptorassociated factor 4 is a dynamic tight junction-related shuttle protein involved in epithelium homeostasis" 3 : e3518-, 2008

      4 Choi I, "Transcription factor AP-2γ is a core regulator of tight junction biogenesis and cavity formation during mouse early embryogenesis" 139 : 4623-4632, 2012

      5 Kidder GM, "Timing of transcription and protein synthesis underlying morphogenesis in preimplantation mouse embryos" 112 : 265-275, 1985

      6 정예린, "Tight Junction Assembly Ensures Maintenance of Pregnancy during Embryogenesis in a Mouse Model" 사단법인 한국동물생명공학회 34 (34): 318-321, 2019

      7 Jeong Y, "The Cxadr-Adam10complex plays pivotal roles in tight junction integrity and early trophoblast development in mice" 86 : 1628-1638, 2019

      8 Kedinger V, "TRAF4, the unique family member" 597 : 60-71, 2007

      9 Rousseau A, "TRAF4, at the crossroad between morphogenesis and cancer" 3 : 2734-2749, 2011

      10 Deng CC, "TRAF4 promotes fibroblast proliferation in keloids by destabilizing p53 via interacting with the deubiquitinase USP10" 139 : 1925-1935.e5, 2019

      1 박윤재, "돼지 정소상체에서 ZO-1, Claudin 1 및 Claudin 4의 발현 양상" 사단법인 한국동물생명공학회 34 (34): 190-196, 2019

      2 Rozan LM, "cand characterization of proteins interacting with Traf4, an enigmatic p53target" 5 : 1228-1235, 2006

      3 Kédinger V, "Tumor necrosis factor receptorassociated factor 4 is a dynamic tight junction-related shuttle protein involved in epithelium homeostasis" 3 : e3518-, 2008

      4 Choi I, "Transcription factor AP-2γ is a core regulator of tight junction biogenesis and cavity formation during mouse early embryogenesis" 139 : 4623-4632, 2012

      5 Kidder GM, "Timing of transcription and protein synthesis underlying morphogenesis in preimplantation mouse embryos" 112 : 265-275, 1985

      6 정예린, "Tight Junction Assembly Ensures Maintenance of Pregnancy during Embryogenesis in a Mouse Model" 사단법인 한국동물생명공학회 34 (34): 318-321, 2019

      7 Jeong Y, "The Cxadr-Adam10complex plays pivotal roles in tight junction integrity and early trophoblast development in mice" 86 : 1628-1638, 2019

      8 Kedinger V, "TRAF4, the unique family member" 597 : 60-71, 2007

      9 Rousseau A, "TRAF4, at the crossroad between morphogenesis and cancer" 3 : 2734-2749, 2011

      10 Deng CC, "TRAF4 promotes fibroblast proliferation in keloids by destabilizing p53 via interacting with the deubiquitinase USP10" 139 : 1925-1935.e5, 2019

      11 Camilleri-Broët S, "TRAF4 overexpression is a common characteristic of human carcinomas" 26 : 142-147, 2007

      12 Watson AJ, "Regulation of blastocyst formation" 6 : D708-D730, 2001

      13 Kwon J, "ROCK activity regulates functional tight junction assembly during blastocyst formation in porcine parthenogenetic embryos" 4 : e1914-, 2016

      14 Muñoz-Espín D, "Programmed cell senescence during mammalian embryonic development" 155 : 1104-1118, 2013

      15 Régnier CH, "Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma" 270 : 25715-25721, 1995

      16 Cockburn K, "Making the blastocyst : lessons from the mouse" 120 : 995-1003, 2010

      17 DongjieZhou, "M-RAS Regulate CDH1 Function in Blastomere Compaction during Porcine Embryonic Development" 사단법인 한국동물생명공학회 35 (35): 12-20, 2020

      18 Xu YC, "Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase" 277 : 28051-28057, 2002

      19 Ock SA, "Involvement of CDKN1A(p21)in cellular senescence in response to heat and irradiation stress during preimplantation development" 25 : 503-508, 2020

      20 Régnier CH, "Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice" 99 : 5585-5590, 2002

      21 Tesarík J, "Developmental control of human preimplantation embryos: a comparative approach" 5 : 347-362, 1988

      22 Kwon J, "Cytoplasmic polyadenylation element binding protein 2(CPEB2)is required for tight-junction assembly for establishment of porcine trophectoderm epithelium" 31 : 412-419, 2019

      23 Kwon JW, "CXADR is required for AJ and TJ assembly during porcine blastocyst formation" 151 : 297-304, 2016

      24 Hoeferlin LA, "Activation of p21-dependent G1/G2 arrest in the absence of DNA damage as an antiapoptotic response to metabolic stress" 2 : 889-899, 2011

      25 Kwon J, "ADAM10 is involved in cell junction assembly in early porcine embryo development" 11 : e0152921-, 2016

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2027 평가예정 재인증평가 신청대상 (재인증)
      2021-01-01 평가 등재학술지 유지 (재인증) KCI등재
      2019-03-14 학회명변경 한글명 : 한국수정란이식학회 -> 사단법인 한국동물생명공학회
      영문명 : The Korean Society Of Embryo Transfer -> The Korean Society of Animal Reproduction and Biotechnology
      KCI등재
      2019-03-12 학술지명변경 한글명 : 한국수정란이식학회지 -> 한국동물생명공학회지
      외국어명 : Korean Journal of Embryo Transfer -> Journal of Animal Reproduciton and Biotechnology
      KCI등재
      2018-01-01 평가 등재학술지 선정 (계속평가) KCI등재
      2017-12-01 평가 등재후보로 하락 (계속평가) KCI등재후보
      2013-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2010-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2007-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2006-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2005-01-01 평가 등재후보 1차 FAIL (등재후보1차) KCI등재후보
      2003-07-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.1 0.1 0.1
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.09 0.08 0.312 0
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