줄기세포의 심혈관계 임상적용 = Clinical application of stem cell in cardiovascular diseases

다국어 초록 (Multilingual Abstract)

Cardiovascular disease has been one of leading causes of death and has an increasing importance in Korea. However the current treatment modalities for cardiovascular disease have limited efficacy. To overcome the limitations of current therapies, stem cell therapy has been evaluated as a new therapeutic option. Most experience and achievements of stem cell therapy for clinical applications have come from bone marrow-derived stem cells. Recent metaanalyses showed that stem cell therapy is safe and effective for improving cardiac systolic functions in patients with acute myocardial infarction. However, the long term efficacy and effects on clinical outcomes need to be determined. Stem cell therapy for acute cardiovascular disease,especially for acute myocardial infarction, has a proven efficacy and safety in short term follow up. Newer stem cell sources and therapeutic approaches such as adjunctive therapy or pretransplantation cultivation will be applied in this field to improve the efficacy of stem cell therapy.
Stem cell therapy is a promising new therapeutic option for cardiovascular disease.

참고문헌 (Reference)

1 Menasche P, "The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) trial: first randomized placebocontrolled study of myoblast transplantation" 117 : 1189-1200, 2008

2 Lunde K, "Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction" 355 : 1199-1209, 2006

3 Schachinger V, "Intracoronary bone marrowderived progenitor cells in acute myocardial infarction" 355 : 1210-1221, 2006

4 Wollert KC, "Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial" 364 : 141-148, 2004

5 Lipinski MJ, "Impact of intracoronary cell therapy on left ventricular function in the setting of acute myocardial infarction: a collaborative systematic review and meta-analysis of controlled clinical trials" 50 : 1761-1767, 2007

6 Chen SL, "Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction" 94 : 92-95, 2004

7 Kang HJ, "Differential effect of intracoronary infusion of mobilized peripheral blood stem cells by granulocyte colony-stimulating factor on left ventricular function and remodeling in patients with acute myocardial infarction versus old myocardial infarction - The" LIPPINCOTT WILLIAMS & WILKINS 114 (114): I145-I151, 200607

8 Meluzin J, "Autologous transplantation of mononuclear bone marrow cells in patients with acute myocardial infarction: the effect of the dose of transplanted cells on myocardial function" 152 : 975.e9-975.e15, 2006

9 Janssens S, "Autologous bone marrowderived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial" 367 : 113-121, 2006