임신초기 이상임신의 진단에서 혈중 hCG와 CA-125치의 의의 = Significance of Serum hCG and CA-125 Level for Detection of Abnormal Pregnancies in First Trimester Pregnancy

다국어 초록 (Multilingual Abstract)

To evaluate the efficacy of ultrasound, serum hCG and CA-125 levels for early detection of abnormal pregnancy in the first trimester of pregnancy, we collected samples from 90 pregnant women who had vaginal spotting. Among them, 27 women continued their pregnancy normally and 63 women were confirmed as abnormal pregnancies pathologically-ectopic pregnancy (30), blight ovum (10), missed abortion (5), fetal demise (10) and molar pregnancy (8). The 95% cofidence interval of serum hCG level in normal pregnant women was 32,000mUI/ml to 398,000mIU/ml. Deversed rates of serum hCG level below 95% confidence interval were 93.8% in women with ectopic pregnancy, 100% in women with missed abortion and fetal demise and 60% in women with blighted ovum. Increased rate of serum hCG level above 95% confidence interval was 67.5% in women with molar pregnancy. The incidence of elevated serum CA-125 level above 35u/ml was 68% in normal pregnant women. The upper limit of 95% confidence interval of serum CA-125 level in normal pregnant women was 150u/ml. We noticed no significant difference of incidence of elevated CA-125 level above 35 u/ml between normal and abnormal pregnant women. Compared to normal pregnant women, however, significant increase of CA-125 level above 150u/ml in women with fetal demise was obtained.