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    Synthesis and Antioxidative Activity of 2-Allyl-4-aminophenol

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    https://www.riss.kr/link?id=A104122814

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    다국어 초록 (Multilingual Abstract) kakao i 다국어 번역

    Antioxidants are effective agents in quenching oxidative damage to biomolecules. Therefore, antioxidant treatments have emerged as a way of reducing oxidative stress-related diseases. Honokiol, a small-molecule polyphenol isolated from the genus Magnolia, shows a wide range of biological activities including antioxidant properties but has inappropriate physicochemical properties. The chemical structure of honokiol was modified and the antioxidative activities of the derivatives were evaluated. Introduction of nitrobenzamide groups at 4-position of 2-allylphenol provided the potent antioxidants which showed better DPPH radical scavenging activities than BHA.
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    Antioxidants are effective agents in quenching oxidative damage to biomolecules. Therefore, antioxidant treatments have emerged as a way of reducing oxidative stress-related diseases. Honokiol, a small-molecule polyphenol isolated from the genus Magno...

    Antioxidants are effective agents in quenching oxidative damage to biomolecules. Therefore, antioxidant treatments have emerged as a way of reducing oxidative stress-related diseases. Honokiol, a small-molecule polyphenol isolated from the genus Magnolia, shows a wide range of biological activities including antioxidant properties but has inappropriate physicochemical properties. The chemical structure of honokiol was modified and the antioxidative activities of the derivatives were evaluated. Introduction of nitrobenzamide groups at 4-position of 2-allylphenol provided the potent antioxidants which showed better DPPH radical scavenging activities than BHA.

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    참고문헌 (Reference)

    1 Huanli X, "Targeting apoptosis pathways in cancer with magnolol and honokiol, bioactive constituents of the bark of Magnolia officinalis" 5 : 202-210, 2011

    2 Kadoma Y, "Radical-scavenging activity of natural methoxyphenols vs. synthetic ones using the induction period method" 12 : 130-138, 2007

    3 Lin Y-R, "Neuroprotective activity of honokiol and magnolol in (erebellar granule cell damage" 537 : 64-69, 2006

    4 Wen J, "Liposomal honokiol inhibits VEGF-D-induced lymphangiogenesis and metastasis in xenograft tumor model" 124 : 2709-2718, 2009

    5 Sharma BK, "Industrial chemistry" Krishna Prakashan 1991

    6 Böhmdorfer M, "In vitro metabolism and disposition of honokiol in rat and human livers" 100 : 3506-3516, 2011

    7 Wang X-H, "Improved solubility and pharmacokinetics of PEGylated liposomal honokiol and human plasma protein binding ability of honokiol" 410 : 169-174, 2011

    8 Lin J-W, "Honokiol traverses the blood-brain barrier and induces apoptosis of neuroblastoma cells via an intrinsic bax-mitochondrioncytochrome c-caspase protease pathway" 14 : 302-314, 2012

    9 Dikalov S, "Honokiol is a potent scavenger of superoxide and peroxyl radicals" 76 : 589-596, 2008

    10 Tse AK-W, "Honokiol inhibits TNF-α-stimulated NF-κB activation and NF-κB-regulated gene expression through suppression of IKK activation" 70 : 1443-1457, 2005

    1 Huanli X, "Targeting apoptosis pathways in cancer with magnolol and honokiol, bioactive constituents of the bark of Magnolia officinalis" 5 : 202-210, 2011

    2 Kadoma Y, "Radical-scavenging activity of natural methoxyphenols vs. synthetic ones using the induction period method" 12 : 130-138, 2007

    3 Lin Y-R, "Neuroprotective activity of honokiol and magnolol in (erebellar granule cell damage" 537 : 64-69, 2006

    4 Wen J, "Liposomal honokiol inhibits VEGF-D-induced lymphangiogenesis and metastasis in xenograft tumor model" 124 : 2709-2718, 2009

    5 Sharma BK, "Industrial chemistry" Krishna Prakashan 1991

    6 Böhmdorfer M, "In vitro metabolism and disposition of honokiol in rat and human livers" 100 : 3506-3516, 2011

    7 Wang X-H, "Improved solubility and pharmacokinetics of PEGylated liposomal honokiol and human plasma protein binding ability of honokiol" 410 : 169-174, 2011

    8 Lin J-W, "Honokiol traverses the blood-brain barrier and induces apoptosis of neuroblastoma cells via an intrinsic bax-mitochondrioncytochrome c-caspase protease pathway" 14 : 302-314, 2012

    9 Dikalov S, "Honokiol is a potent scavenger of superoxide and peroxyl radicals" 76 : 589-596, 2008

    10 Tse AK-W, "Honokiol inhibits TNF-α-stimulated NF-κB activation and NF-κB-regulated gene expression through suppression of IKK activation" 70 : 1443-1457, 2005

    11 Valko M, "Free radicals and antioxidants in normal physiological functions and human disease" 39 : 44-84, 2007

    12 Zhao C, "Comparison of antioxidant abilities of magnolol and honokiol to scavenge radicals and to protect DNA" 93 : 1755-1760, 2011

    13 Grenier J-L, "Antioxidant properties of nitrocaffeic acids" 6 : 431-434, 1996

    14 Gülçin. I, "Antioxidant activity of food constituents : an overview" 86 : 345-391, 2012

    15 Erkan N, "Antioxidant activities of rosemary (Rosmarinus officinalis L.) extract, blackseed (Nigella sativa L.) essential oil, carnosic acid, rosmarinic acid and sesamol" 110 : 76-82, 2008

    16 Lee J, "Anti-inflammatory effects of magnolol and honokiol are mediated through inhibition of the downstream pathway of MEKK-1 in NF-κB activation signaling" 71 : 338-343, 2005

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    학술지 이력

    학술지 이력
    연월일 이력구분 이력상세 등재구분
    2027 평가 재인증평가 신청대상 (재인증)
    2021-01-01 등재 등재학술지 유지 (재인증) KCI등재
    2018-01-01 등재 등재학술지 선정 (계속평가) KCI등재
    2016-01-01 등재 등재후보학술지 선정 (신규평가) KCI등재후보
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    학술지 인용정보

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    기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
    2016 0.09 0.09 0.08
    KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
    0 0 0.343 0.1
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