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      KCI등재 SCIE SCOPUS

      Classification of Breast Cancer Histopathological Images using Residual Learning-based CNN

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      https://www.riss.kr/link?id=A109493213

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      다국어 초록 (Multilingual Abstract) kakao i 다국어 번역

      Among the most popular methods for diagnosing breast cancer in women is a biopsy, in which tissue is taken out and examined under a microscope via a pathologist to search for anomalies in the tissue. This method can be laborious, prone to mistakes, and yield inconsistent outcomes based on the pathologist's degree of experience. In this research, for detecting breast cancer tumors, an automated method based on histopathology images is used. With the proposed technique, a convolutional neural network (CNN) of the dimensions 152-layers is utilized for breast cancer histopathology image categorization called ResHist, which depends on residual learning. Furthermore, we construct a data augmentation strategy using affine transformation, image patch creation, and stain normalization to improve the accuracy of the designed model.
      Additionally, if data augmentation is used, this method obtains F1-score of 93.45% and an accuracy of 92.52%. For the purpose of classifying malignant and benign histological images, the suggested method performs better than the current approaches. Additionally, our research findings show that our method outperforms the pre-trained networks in the classifying the histopathological images, including ResNet152, ResNet50, Inception-v3, GoogleNet, VGG19, VGG16, and AlexNet.
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      Among the most popular methods for diagnosing breast cancer in women is a biopsy, in which tissue is taken out and examined under a microscope via a pathologist to search for anomalies in the tissue. This method can be laborious, prone to mistakes, an...

      Among the most popular methods for diagnosing breast cancer in women is a biopsy, in which tissue is taken out and examined under a microscope via a pathologist to search for anomalies in the tissue. This method can be laborious, prone to mistakes, and yield inconsistent outcomes based on the pathologist's degree of experience. In this research, for detecting breast cancer tumors, an automated method based on histopathology images is used. With the proposed technique, a convolutional neural network (CNN) of the dimensions 152-layers is utilized for breast cancer histopathology image categorization called ResHist, which depends on residual learning. Furthermore, we construct a data augmentation strategy using affine transformation, image patch creation, and stain normalization to improve the accuracy of the designed model.
      Additionally, if data augmentation is used, this method obtains F1-score of 93.45% and an accuracy of 92.52%. For the purpose of classifying malignant and benign histological images, the suggested method performs better than the current approaches. Additionally, our research findings show that our method outperforms the pre-trained networks in the classifying the histopathological images, including ResNet152, ResNet50, Inception-v3, GoogleNet, VGG19, VGG16, and AlexNet.

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      참고문헌 (Reference)

      1 P. Boyle, "World Cancer Report 2008" IARC 2008

      2 K. Simonyan, "Very Deep Convolutional Networks for Large-Scale Image Recognition"

      3 S. C. Wong, "Understanding Data Augmentation for Classification : When to Warp?" 1-6, 2016

      4 C. Cortes, "Support-vector networks" 20 : 273-297, 1995

      5 "Skin Cancer, Malignant vs. Benign dataset"

      6 C. Lam, "Retinal Lesion Detection With Deep Learning Using Image Patches" 59 (59): 590-596, 2018

      7 C. Szegedy, "Rethinking the Inception Architecture for Computer Vision" 2818-2826, 2016

      8 Y. M. George, "Remote Computer-Aided Breast Cancer Detection and Diagnosis System Based on Cytological Images" 8 (8): 949-964, 2014

      9 L. Breiman, "Random forests" 45 : 5-32, 2001

      10 A. A. A. Setio, "Pulmonary Nodule Detection in CT Images: False Positive Reduction Using Multi-View Convolutional Networks" 35 (35): 1160-1169, 2016

      1 P. Boyle, "World Cancer Report 2008" IARC 2008

      2 K. Simonyan, "Very Deep Convolutional Networks for Large-Scale Image Recognition"

      3 S. C. Wong, "Understanding Data Augmentation for Classification : When to Warp?" 1-6, 2016

      4 C. Cortes, "Support-vector networks" 20 : 273-297, 1995

      5 "Skin Cancer, Malignant vs. Benign dataset"

      6 C. Lam, "Retinal Lesion Detection With Deep Learning Using Image Patches" 59 (59): 590-596, 2018

      7 C. Szegedy, "Rethinking the Inception Architecture for Computer Vision" 2818-2826, 2016

      8 Y. M. George, "Remote Computer-Aided Breast Cancer Detection and Diagnosis System Based on Cytological Images" 8 (8): 949-964, 2014

      9 L. Breiman, "Random forests" 45 : 5-32, 2001

      10 A. A. A. Setio, "Pulmonary Nodule Detection in CT Images: False Positive Reduction Using Multi-View Convolutional Networks" 35 (35): 1160-1169, 2016

      11 P. Naylor, "Nuclei segmentation in histopathology images using deep neural networks" 933-936, 2017

      12 P. J. Sudharshan, "Multiple instance learning for histopathological breast cancer image classification" 117 : 103-111, 2019

      13 J. P. Shaffer, "Modified Sequentially Rejective Multiple Test Procedures" 81 (81): 826-831, 1986

      14 "Malaria Datasets"

      15 L. E. Peterson, "K-nearest neighbor" 4 (4): 2009

      16 A. Krizhevsky, "ImageNet Classification with Deep Convolutional Neural Networks" 1097-1105, 2012

      17 L. He, "Histology image analysis for carcinoma detection and grading" 107 (107): 538-556, 2012

      18 C. Szegedy, "Going deeper with convolutions" 1-9, 2015

      19 S. Ren, "Faster R-CNN : Towards Real-Time Object Detection with Region Proposal Networks" 39 (39): 1137-1149, 2017

      20 P. Li, "Deep visual tracking : Review and experimental comparison" 76 : 323-338, 2018

      21 N. Bayramoglu, "Deep learning for magnification independent breast cancer histopathology image classification" 2440-2445, 2016

      22 F. A. Spanhol, "Deep features for breast cancer histopathological image classification" 1868-1873, 2017

      23 J. P. Dominguez-Morales, "Deep Spiking Neural Network model for time-variant signals classification : a real-time speech recognition approach" 1-8, 2018

      24 K. He, "Deep Residual Learning for Image Recognition" 770-778, 2016

      25 J. Kleesiek, "Deep MRI brain extraction: a 3D convolutional neural network for skull stripping" 129 : 460-469, 2016

      26 I. Goodfellow, "Deep Learning" MIT Press 2016

      27 "Covid-chest X-ray-dataset"

      28 O. Abdel-Hamid, "Convolutional Neural Networks for Speech Recognition" 22 (22): 1533-1545, 2014

      29 B. Stenkvist, "Computerized nuclear morphometry as an objective method for characterizing human cancer cell populations" 38 (38): 4688-4697, 1978

      30 M. Kowal, "Computer-aided diagnosis of breast cancer based on fine needle biopsy microscopic images" 43 (43): 1563-1572, 2013

      31 D. Magee, "Colour Normalisation in Digital Histopathology Images" 100-110, 2009

      32 F. A. Spanhol, "Breast cancer histopathological image classification using convolutional neural networks" 2560-2567, 2016

      33 H. Lu, "Brain Intelligence : Go beyond Artificial Intelligence" 23 : 368-375, 2018

      34 S. Ioffe, "Batch Normalization: Accelerating Deep Network Training by Reducing Internal Covariate Shift"

      35 M. Talo, "Application of deep transfer learning for automated brain abnormality classification using MR images" 54 : 176-188, 2019

      36 D. P. Kingma, "Adam: A Method for Stochastic Optimization"

      37 S. Holm, "A Simple Sequentially Rejective Multiple Test Procedure" 6 (6): 65-70, 1979

      38 F. A. Spanhol, "A Dataset for Breast Cancer Histopathological Image Classification" 63 (63): 1455-1462, 2016

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