랫드에서 비스페놀 A의 발생독성에 대한 고려홍삼 물추출물의 효과 = Effects of Korean Red Ginseng Water Extract on Bisphenol A-induced Developmental Toxicity in Rats

다국어 초록 (Multilingual Abstract)

The present study was conducted to investigate the effects of Korean red ginseng water extract (KRGWE) on developmental toxicity caused by the environmental estrogen bisphenol A (BPA) in Sprague-Dawley rats. Fifty females successfully mated were randomly assigned to five experimental groups, i.e., group Ⅰ (vehicle control), group Ⅱ (BPA 1000mg/kg), group Ⅲ (KRGWE 400 mg/kg), group Ⅳ (BPA 1000mg/kg & KRGWE 200mg/kg), and group Ⅴ (BPA 1000mg/kg & KRGWE 400mg/kg). The test articles were administered by gavage to mated females from gestational days (GD) 1 through 20 (sperm vaginal lavage = day 0). All females were subjected to caesarean section on GD 21 and their fetuses were examined for external, visceral, and skeletal abnormalities. In the group Ⅱ, significant maternal toxic effects including suppressed body weight, decreased body weight gain during pregnancy, and reduced food consumption were observed in pregnant rats. The minimal developmental toxicity including fetal ossification delay was also found in fetuses. In addition, a tendency for increased pregnancy failure, increased pre- and postimplantation loss, and decreased fetal body weight was observed. However, no fetal morphological abnormalities were seen in surviving fetuses at a dose level of 1000mg BPA/kg. On the other hand, the maternal toxicity and developmental toxicity found in the groups Ⅳ and Ⅴ were comparable to those of the group Ⅱ. There were no adverse signs of either maternal toxicity or developmental toxicity in the group Ⅲ. These results showed that administration of BPA at a dose level of 1000mg/kg to pregnant rats resulted in significant maternal toxicity and minimal developmental toxicity, and that no protective effects on BPA-induced maternal toxicity and developmental toxicity were found by concomitant gavage dosing of KRGWE.