當歸鬚散이 實驗的 白鼠肝 瘀血에 미치는 影響 = Experimental Studies on the Effect of Dangkwisoo-San on the CCI₄-Induced Liver Damange in Albino-Rats

다국어 초록 (Multilingual Abstract)

Dengkwisoo-San has been applied to various conditions with congestions and extravasated blood in the Oriental Medicine. The effectiveness of Dangkwisoo-San on the repair of carbon tetrachloride ( CCl₄) induced-liver damage in Albino rats was biochemically and histologically studied.
The results were summarized as follows :
1. Dangkwisoo-San had a reducing action of serum alkaline phosphatase, alpha-hydroxy-butyrate dehydrogenase, lactate dehydrogenase, leucine aminopeptidase, glutamic oxalacetic transaminase and glutamic pyrubic transaminase activities of the rats pretreated with CCl₄.
2. Dangkwisoo-San had an action of increase in serum albumin and total protein without interference with serum globulin values of the rate pretreated with CCl₄.
3. Dangkwisoo-San appeared to promote restoration of the impaired functions following congestion, necrosis and fatty change of hepatic cells damaged by CCl₄injection, and the repair process was manifested by a slight increase in periodic acid Schiff positive substances it necrotic hepatocytes.
4. The effect of Dangkwisoo-San was observed biochemically and histologcally 48 hours after the administration of the preparation.
5. No clear-cut difference on the effect of Dangkwisoo-San was present between types (decoction or extract) and dosages of the preparation prescribed.
In summary of the experimental results described above, Dangkwisoo-San appeared helpful for promoting repair of liver cell necrosis followed by congestion, and it was suggested that Dangkwisoo-San was effective on liver cell damage.

목차 (Table of Contents)

• Summary
• Ⅰ. 緖 論
• Ⅱ. 實驗材料 및 方法
• 1. 實驗動物
• 2. 當歸鬚散
• 3. 實驗方法
• Ⅲ. 實驗成績
• 1. 生化學的 成績
• 2. 組織學的 및 組織化學的 檢索
• Ⅳ. 考 察
• Ⅴ. 結 論
• 參考文獻
• 사진설명
• 사진부도