원위세뇨관 상피세포 전해질 이동모델 = Epithelial Transport Model for the Renal Distal Tubule

다국어 초록 (Multilingual Abstract)

A mathematical model describing epithelial transport of the early distal tubule was formulated based on the principles of mass conservation and maintenance of electroneutrality within the cells and luminal and interstitial solutions. Solute movement across membrane is assumed to occur passively by electrodiffusion, active transport, and/or cotransport Although the model was formulated for the early distal tubule, it is independent of the specific membrane transport mechanisms, and can be used to evaluate different epithelial cells by including different transport mechanisms. This model allows both transient and steady-state responses under open-circuit and voltage-clamp conditions. For specific purpose here, this model includes apical Na＾(+), K＾(+), Cl＾(-) permeabilities and NaCl contransport, and basolateral Na＾(+), K＾(+)-ATPase and K＾(+) and Cl＾(-) permeabilities. In evulating this model, model results in response to changes in luminal Na＾(+) in open-circuit case and transepithelial potential in closed-circuit(voltage clamp) case were subjected to the test of reasonability.