SURF4 has oncogenic potential in NIH3T3 cells

다국어 초록 (Multilingual Abstract)

<P><B>Abstract</B></P> <P>SURF4, which is located in the Surfeit gene cluster, encodes for a conserved integral membrane protein containing multiple putative transmembrane regions. However, the physiological role of SURF4 has not been determined. We found that <I>SURF4</I> demonstrated aberrant amplification and increased expression in the tumor tissues of several human cancer patients. Overexpression of SURF4 led to increased cell proliferation, migration, and maintenance of anchorage-independent growth. In addition, NIH3T3 cells overexpressing SURF4 induced tumor growth in the mice. Collectively, our findings demonstrate that SURF4 has the potential for inducing cellular transformation and cell migration <I>in vitro</I> and has oncogenic transformation ability <I>in vivo</I>.</P> <P><B>Highlights</B></P> <P> <UL> <LI> <I>SURF4</I> was found to be amplified and highly expressed in the tumor tissues of several human cancer patients. </LI> <LI> Patients with tumors exhibiting high <I>SURF4</I> expression had significantly shorter overall survival than low <I>SURF4</I> expression. </LI> <LI> <I>SURF4</I> can induce cellular transformation and cell migration <I>in vitro</I> and promotes oncogenic transformation <I>in vivo.</I> </LI> </UL> </P>