<P><B>Abstract</B></P> <P>A series of <I>N</I>-methoxyamide derivatives was identified and evaluated as GPR119 agonists. Several <I>N</I>-methoxyamides with thienopyrimidine and pyridine scaffolds...
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https://www.riss.kr/link?id=A107437471
2017
-
SCI,SCIE,SCOPUS
학술저널
3909-3914(6쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P><B>Abstract</B></P> <P>A series of <I>N</I>-methoxyamide derivatives was identified and evaluated as GPR119 agonists. Several <I>N</I>-methoxyamides with thienopyrimidine and pyridine scaffolds...
<P><B>Abstract</B></P> <P>A series of <I>N</I>-methoxyamide derivatives was identified and evaluated as GPR119 agonists. Several <I>N</I>-methoxyamides with thienopyrimidine and pyridine scaffolds showed potent GPR119 agonistic activities. Among them, compound <B>9c</B> displayed good in vitro activity and potency. Moreover, compound <B>9c</B> lowered glucose excursion in mice in an oral glucose tolerance test and increased GLP-1 secretion in intestinal cells.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
AuNP-CTG based probing system targeting CAG repeat DNA and RNA sequences