만성활동성간염에서의 (慢性活動性肝炎) HBs Ag 및 자기항체출현빈도의 (自己抗體出現瀕度) 지리적 차이 - 서울과 New York 환자의 비교관찰 - = Geographical Variations on the Incidence of HBs Ag and Autoantibodies in Chronic Active Hepatits - Comparison of Patients in Seoul and New York City -

다국어 초록 (Multilingual Abstract)

The sera of 28 patients from Korea with biopsy- proven chronic active hepatitis (CAH) and 54 control subjects were examined for HBs Ag by a solid-phase double-antibody radio-immunoassay technique and for autoantibodies to mitochondria, smooth muscle, and nuclei by the fluorescent-antibody technique using human kidney, liver, and rat stomach as substrates. Eighty-six per cent of sera of patients with CAH contained HBs Ag. In a control group of apparently normal subjecis and subject with miscellaneous liver diseases unrel ted to vira! Hcpatilis. HBs Ag was observed in 17,a of zere. A!1 patients had hI3s Ag, ad subtype. Antibodies to mitcchondria or nuc! I were not detected in the s'r,. Cf pa,ients vitii. CAH. Oillp' v pc.'.'f:ilt:, ilBu IC\W' it.S G.I IT'Gcir;I Il'.',1... Anti'iodies, 2 in iHBs Ag posit'.;c a;3 1 in HP..; Ag negative ca;es. In con'.rast, simiiar I:.rcstigatio-s p=rfcrrne<' in '.he same!aboratory on 100 pntie,-ts frcrn l;e;v York City with CA.I inciica!ed a !ov;er iic!d-...e of HR a..tig- enerr.ia .,7%) a..socia!ed with smo'.h musc!e ar.ti'o- odies,ui.o, or:iuc:.ar cnti =:.I.-s ,', o,', !.u'; I;nt ivith mit I 1GilCI.B. B'..I:3i2-2. The suLlyp v, as F.Bs Ag j'ad I;I 10 I cf 1 pati ts invstigatecl. Tiie resu!ts suggest t!:a'. Eogr apliical or ger.etic .'la I.:r. rna,' ac'r;uzt f.;:::!,' cl!ffi.rr:;,- .; in the inc!dcr.c of hBs Ag and,:u.',:,-,>,l>nclis I. C AH. Furiher, I( tl:e hypot!:eis t!;at C:.H is u clis-.ase with mu!tip!e etio!ogies is cr.rrec!, in Kc.-;: f;H is mair.Iy rclated to FiRs Ag.