Neuroprotective and cognitive enhancing effect of Annona muricata in mice

다국어 초록 (Multilingual Abstract)

The number of a Alzheimer disease's(AD) is increasing as the aging society progresses. AD accompanies memory and behavioral disorders. Since the mechanisms that cause AD are not yet known, studies on the therapeutic agents of this disease have been actively conducted. We examined whether Annona muricata, a natural product, was effective in treating AD. A. muricata is mainly distributed in the tropics of America. This plant traditionally called 'natural remedy' or 'God's gift' and has been used as a treatment for American native. A. muricata contains compounds such as tannin, saponin, flavonoid and antraquinone. We conducted the Morris water meze test and Passive avoidance test with MeOH extracts of A. muricata. Morris water maze test is performed to verify spatial learning abilities. Passive avoidance test is an experiment to check the memory of pain or aversive stimuli. In this study, we confirmed the effects of A. muricata in amnesia mice. We used scopolamine to induce memory and behavioral disturbances. A. muricata shortened the time it took for mice to arrive at buoys in Morris water maze test. In passive avoidance test, A. muricata reduce the latency time. And we have conducted an MTT assay to determine if A. muricata ha cytoprotective effects, and that the high concentrations of A. muricata are effective for cell protection. These results confirm that A. muricata has the effect of ameliorating the symptoms of amnesia mice. It also suggests that this plant has potential for treatment or prevention of AD.