Ranitidine, Sucralfate, Bismuth Subcitrate 복합제의 흰쥐 위궤양에 대한 치료효과 = Effects of the Mixture of Ranitidine, Sucralfate and Bismuth Subcitrate on Gastric Ulcer in Rats

다국어 초록 (Multilingual Abstract)

Gastric ulcer disease results when there is an imbalance between aggressive factors(acid secretion) and protective factors(mucosal defence). H_2-receptor antagonists are the most frequently used agents for treatment of gastric ulcer disease. However, use of these products should be determined by potential for adverse effects, drug interactions and cost.
Ranitidine, H_2 - receptor antagonist, competitively block the H_Z-receptor on the parietal cell, causing inhibition of gastric acid secretion. Sucralfate and bismuth subcitrate coat ulcer craters and then enhance mucosal defence. Bismuth subcitrate also causes detachment of Helicobacter pylori from the gastric epithelium with subsequent lysis of the bacteria.
To estimate effects of the mixture of ranitidine 20mg/kg, bismuth subcitrate 40mg/kg and sucralfate 120mg/kg on aspirin - HCl induced gastric ulcer in rats, gastric ulceration, pH, gastric secretion, free and total acidity, pepsin activity, gastric mucosal hemorrhage were investigated.
Results obtained were as follow : 1) The mixture showed remarkable suppression of gastric ulceration, pH, gastric secretion, free and total acidity, pepsin activity, gastric mucosal hemorrhage compared with ranitidine alone. 2) With elapse of time, the mixture showed more increasing inhibitory effects on gastric ulceration, pH, gastric secretion, pepsin activity, gastric mucosal hemorrhage than sucralfate and bismuth subcitrate.