지난 50년간 국내 항생제 내성의 변화와 향후 전망 - 그람음성 세균 = Trend of Bacterial Resistance for the Past 50 Years in Korea and Future Perspectives – Gram-negative Bacteria

다국어 초록 (Multilingual Abstract)

The increasing prevalence of antimicrobial-resistant bacteria has become a serious problem in many parts of the world, including Korea. The resistance of of Grampositive cocci was once considered to be a more serious problem, but the recent emergence of multi-resistant Gram-negative bacilli has raised great concerns. In Korea, the prevalence of ESBL-producing Escherichia coli and Klebsiella pneumoniae and fluoroquinolone-resistant E. coli , K. pneumoniae, Acinetobacter spp., and Pseudomonas aeruginosa has gradually increased. The increase in imipenem resistance was slight in P. aeruginosa , but drastic in Acinetobacter spp. It is certain that problematic antimicrobial-organism combinations are prevalent in Korea, increase of resistant bacteria will continue in the future. The development of new antimicrobial agents is considered difficult. Therefore, it is very important to use existing antimicrobial agents prudently, to extend the efficacy, to prevent infections, and tostrengthen infection control measures to prevent spread of resistant bacteria.

참고문헌 (Reference)

1 송원근, "국내의 Acinetobacter baumannii와 Pseudomonas aeruginosa 임상분리주에 대한 Colistin과 Polymyxin B의 감수성 양상" 대한감염학회 38 (38): 362-366, 2006

2 Lee K, "blaVIM-2 cassettes-containing novel integrons in metallo- β-lactamase-producing Pseudomonas aeruginosa and Pseudomonas putida isolates disseminated in a Korean hospital" 46 : 1053-1058, 2002

3 Lee K, "Wide dissemination of OXA-type carbapenemases in clinical Acinetobacter spp. isolates from South Korea" 33 (33): 520-524, 2009

4 Lee K, "VIMand IMP-type metallo-β-lactamase-producing Pseudomonas spp. and Acinetobacter spp. in Korean hospitals" 9 : 868-871, 2003

5 Kim SI, "Trend of antimicrobial usage in Korea" 2011

6 Chong Y, "Trend of antimicrobial agent resistance of bacteria isolated from clinical materials" 21 : 243-255, 1989

7 Watanabe M, "Transferable imipenem resistance in Pseudomonas aeruginosa" 35 : 147-151, 1991

8 Robicsek A, "The worldwide emergence of plasmid-mediated quinolone resistance" 6 : 629-640, 2006

9 Chung HY, "The changing pattern of antimicrobial susceptibility of hospital isolates" 18 : 1-10, 1986

10 Pai H, "Survey of extended-spectrum β-lactamases in clinical isolates of Escherichia coli and Klebsiella pneumoniae: prevalence of TEM-52 in Korea" 37 : 1758-1763, 1999

11 Kim J, "Survey of Klebsiella pneumoniae strains producing extended-spectrum β-lactamases: prevalence of SHV-12 and SHV-2a in Korea" 36 : 1446-1449, 1998

12 Song JH, "Spread of methicillinresistant Staphylococcus aureus between the community and the hospitals in Asian countries: an ANSORP study" 66 : 1061-1069, 2011

13 Donald HM, "Sequence analysis of ARI-1, a novel OXA β-lactamase, responsible for imipenem resistance in Acinetobacter baumannii 6B92" 44 : 196-199, 2000

14 Barnaud G, "Salmonella enteritidis: AmpC plasmid-mediated inducible β-lactamase (DHA-1) with an ampR gene from Morganella morganii" 42 : 2352-2358, 1998

15 Lee K, "Reduced imipenem susceptibility in Klebsiella pneumoniae clinical isolates with plasmid-mediated CMY-2 and DHA-1 β-lactamases co-mediated by porin loss" 29 : 201-206, 2007

16 Chong Y, "Quality control of antibiotic susceptibility testing" 20 : 433-440, 1977

17 Naas T, "Pyrosequencing for rapid identification of carbapenem-hydrolyzing OXA-type β-lactamases in Acinetobacter baumannii" 12 : 1236-1240, 2006

18 Lee K, "Prevalence of plasmid-mediated AmpC β-lactamases in Escherichia coli and Klebsiella pneumoniae in Korea" 12 (12): 44-49, 2006

19 Lee K, "Prevalence of extended broad-spectrum β-lactamase in Escherichia coli and Klebsiella pneumoniae" 26 : 341-348, 1994

20 Kim J, "Prevalence of derepressed ampC mutants and extended-spectrum β-lactamase producers among clinical isolates of Citrobacter freundii, Enterobacter spp., and Serratia marcescens in Korea: dissemination of CTX-M-3, TEM-52, and SHV-12" 43 : 2452-2455, 2005

21 정행순, "Prevalence of Plasmid-mediated Quinolone Resistance and Its Association with Extended-spectrum Beta-lactamase and AmpC Beta-lactamase in Enterobacteriaceae" 대한진단검사의학회 31 (31): 257-264, 2011

22 Park YJ, "Prevalence and diversity of qnr alleles in AmpC-producing Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii and Serratia marcescens: a multi-centre study from Korea" 60 : 868-871, 2007

23 Kim CK, "Prevalence and diversity of carbapenemases among imipenem-nonsusceptible Acinetobacter isolates in Korea: emergence of a novel OXA-182" Elsevier BV 68 (68): 432-438, 2010

24 Brötz-Oesterhelt H, "Postgenomic strategies in antibacterial drug discovery" 5 : 1553-1579, 2010

25 Hossain A, "Plasmidmediated carbapenem-hydrolyzing enzyme KPC-2 in an Enterobacter sp" 48 : 4438-4440, 2004

26 Galimand M, "Plasmid-mediated high-level resistance to aminoglycosides in Enterobacteriaceae due to 16S rRNA methylation" 47 : 2565-2571, 2003

27 Naas T, "Plasmid-mediated carbapenem-hydrolyzing β-lactamase KPC in a Klebsiella pneumonia isolate from France" 49 : 4423-4424, 2005

28 National Committee for Clinical Laboratory Standards, "Performance standards for antimicrobial disk susceptibility tests-proposed standard" NCCLS 1975

29 Park SH, "Pathogenic bacteria isolated from Korean patients" 1 : 33-48, 1969

30 Ryoo NH, "Outbreak by meropenem-resistant Pseudomonas aeruginosa producing IMP-6 metallo-beta-lactamase in a Korean hospital" 63 : 115-115~117, 2009

31 Park YJ, "Occurrence of extended-spectrum β-lactamases and plasmid-mediated AmpC β-lactamases among Korean isolates of Proteus mirabilis" OXFORD UNIV PRESS 57 (57): 156-158, 2006

32 Park YJ, "Occurrence of extended-spectrum β-lactamases among chromosomal AmpC-producing Enterobacter cloacae, Citrobacter freundii, and Serratia marcescens in Korea and investigation of screening criteria" 51 (51): 265-269, 2005

33 Walther-Rasmussen J, "OXA-type carbapenemases" 57 : 373-383, 2006

34 Papanicolaou GA, "Novel plasmidmediated β-lactamase (MIR-1) conferring resistance to oxyimino- and alpha-methoxy β-lactams in clinical isolates of Klebsiella pneumoniae" 34 : 2200-2209, 1990

35 Yigit H, "Novel carbapenem-hydrolyzing β-lactamase, KPC-1, from a carbapenem- resistant strain of Klebsiella pneumoniae" 45 : 1151-1161, 2001

36 Lee K, "Novel acquired metallo-β-lactamase gene, blaSIM-1, n a class integron from Acinetobacter baumannii clinical isolates from Korea" 49 : 4485-4491, 2005

37 이경원, "Multidrug-Resistant Acinetobacter spp.: Increasingly Problematic Nosocomial Pathogens" 연세대학교의과대학 52 (52): 879-891, 2011

38 Yum JH, "Molecular characterization of metallo-β-lactamaseproducing Acinetobacter baumannii and Acinetobacter genomospecies 3 from Korea: identification of two novel integrons carrying blaVIM-2 gene cassettes" 49 : 837-840, 2002

39 Walsh TR, "Metallo-β- lactamases: the quiet before the storm" 18 : 306-325, 2005

40 Gupta V, "Metallo β-lactamases in Pseudomonas aeruginosa and Acinetobacter species" 17 : 131-143, 2008

41 Chong Y, "Korean nationwide surveillance of antimicrobial resistance of bacteria in 1997" 39 : 569-577, 1998

42 Rhee JY, "KPC-producing extreme drug-resistant Klebsiella pneumoniae isolate from a patient with diabetes mellitus and chronic renal failure on hemodialysis in South Korea" 54 : 2278-2279, 2010

43 Sekiguchi J, "KHM-1, a novel plasmid-mediated metallo-β-lactamase from a Citrobacter freundii clinical isolate" 52 : 4194-4197, 2008

44 노경호, "Isolation of a Klebsiella pneumoniae Isolate of Sequence Type 258 Producing KPC-2 Carbapenemase in Korea" 대한진단검사의학회 31 (31): 298-301, 2011

45 Jeong SH, "Investigation of extended-spectrum β-lactamases produced by clinical isolates of Klebsiella pneumoniae and Escherichia coli in Korea" 39 (39): 41-47, 2004

46 Bradford PA, "Imipenem resistance in Klebsiella pneumoniae is associated with the combination of ACT-1, a plasmid-mediated AmpC β-lactamase, and the foss of an outer membrane protein" 41 : 563-569, 1997

47 Tzouvelekis LS, "Identification of a novel plasmid-mediated β-lactamase with chromosomal cephalosporinase characteristics from Klebsiella pneumoniae" 31 : 645-654, 1993

48 Pai H, "Identification of CTX-M-14 extended-spectrum β-lactamase in clinical isolates of Shigella sonnei, Escherichia coli, and Klebsiella pneumoniae in Korea" 39 : 3747-3749, 2001

49 Ko KS, "High rates of resistance to colistin and polymyxin B in subgroups of Acinetobacter baumannii isolates from Korea" OXFORD UNIV PRESS 60 (60): 1163-1167, 2007

50 Yoo JS, "High prevalence of extended-spectrum β-lactamases and plasmidmediated AmpC β-lactamases in Enterobacteriaceae isolated from long-term care facilities in Korea" 67 : 261-265, 2010

51 Pai H, "High prevalence of extended-spectrum β-lactamase-producing strains among blood isolates of Enterobacter spp. collected in a tertiary hospital during an 8-year period and their antimicrobial susceptibility patterns" 48 : 3159-3161, 2004

52 Bonnet R, "Growing group of extended-spectrum β-lactamases: the CTX-M enzymes" 48 : 1-14, 2004

53 Gonzalez Leiza M, "Gene sequence and biochemical characterization of FOX-1 from Klebsiella pneumoniae, a new AmpC-type plasmid-mediated β-lactamase with two molecular variants" 38 : 2150-2157, 1994

54 Kyungwon Lee, "Further Increases in Carbapenem-, Amikacin-, and Fluoroquinolone-Resistant Isolates of Acinetobacter spp. and P. aeruginosa in Korea: KONSAR Study 2009" 연세대학교의과대학 52 (52): 793-802, 2011

55 Villegas MV, "First detection of the plasmid-mediated class A carbapenemase KPC-2 in clinical isolates of Klebsiella pneumoniae from South America" 50 : 2880-2882, 2006

56 Paterson DL, "Extended-spectrum β-lactamases: a clinical update" 18 : 657-686, 2005

57 Bradford PA, "Extended-spectrum β-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat" 14 : 933-951, 2001

58 Bauernfeind A, "Extended broad spectrum β-lactamase in Klebsiella pneumoniae including resistance to cephamycins" 17 : 316-321, 1989

59 Lee K, "Evolution of resistance and spread of multidrug-resistant bacteria" Seo Heung Publishing co 2007

60 Shah PM, "Escherichia coli and Klebsiella pneumoniae strains more susceptible to cefoxitin than to third generation cephalosporins" 11 : 598-598, 1983

61 Hooper DC, "Emerging mechanisms of fluoroquinolone resistance" 7 : 337-341, 2001

62 Bradford PA, "Emergence of carbapenem-resistant Klebsiella species possessing the class A carbapenem-hydrolyzing KPC-2 and inhibitor-resistant TEM-30 β-lactamases in New York City" 39 : 55-60, 2004

63 Yoo J, "Emergence of KPC-2 producing Klebsiella pneumoniae ST258 isolates from national surveillance for carbapenem-resistant Enterobacteriaceae (CRE) in Korea" 2011

64 Lee K, "Diversity of TEM- 52 extended-spectrum β-lactamase-producing non-typhoidal Salmonella isolates in Korea" 52 : 493-496, 2003

65 Lee H, "Dissemination of 16S rRNA methylase-mediated highly amikacin-resistant isolates of Klebsiella pneumoniae and Acinetobacter baumannii in Korea" 56 : 305-312, 2006

66 Jeong JY, "Detection of qnr in clinical isolates of Escherichia coli from Korea" AMER SOC MICROBIOLOGY 49 (49): 2522-2524, 2005

67 Kallen AJ, "Current epidemiology of multidrugresistant gram-negative bacilli in the United States" 31 (31): S51-S54, 2010

68 Lai CC, "Correlation between antibiotic consumption and resistance of Gram-negative bacteria causing healthcare- associated infections at a university hospital in Taiwan from 2000 to 2009" 66 : 1374-1382, 2011

69 Park YJ, "Co-production of 16S rRNA methylases and extended-spectrum β-lactamases in AmpC-producing Enterobacter cloacae, Citrobacter freundii and Serratia marcescens in Korea [12]" OXFORD UNIV PRESS 58 : 907-908, 2006

70 Fosberry AP, "Cloning and sequence analysis of blaBIL-1, a plasmid-mediated class C β-lactamase gene in Escherichia coli BS" 38 : 1182-1185, 1994

71 Song W, "Chromosome-Encoded AmpC and CTX-M Extended-Spectrum beta-Lactamases in Clinical Isolates of Proteus mirabilis from Korea" AMER SOC MICROBIOLOGY 55 (55): 1414-1419, 2011

72 Pai H, "Characterization of extended spectrum β-lactamase in Klebsiella pneumoniae isolated in Korea" 29 : 93-103, 1997

73 Horii T, "Characterization of a plasmid-borne and constitutively expressed blaMOX-1 gene encoding AmpC-type β-lactamase" 139 : 93-98, 1994

74 "Characterization of a new integron containing VIM-2, a metallo-beta-lactamase gene cassette, in a clinical isolate of Enterobacter cloacae" 51 : 397-400, 200302

75 Yong D, "Characterization of a New Metallo-beta-Lactamase Gene, bla(NDM-1), and a Novel Erythromycin Esterase Gene Carried on a Unique Genetic Structure in Klebsiella pneumoniae Sequence Type 14 from India" 53 (53): 5046-5054, 2009

76 Afzal-Shah M, "Characterization of OXA-25, OXA-26, and OXA-27, molecular class D β-lactamases associated with carbapenem resistance in clinical isolates of Acinetobacter baumannii" 45 : 583-588, 2001

77 Kim MN, "Characterization of NDM-1-producing Klebsiella pneumoniae isolated from four Korean patients within a month" 2011

78 Poirel L, "Characterization of DIM-1, an integron-encoded metallo-β-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands" 54 : 2420-2424, 2010

79 Chong Y, "Characteristics of extended- spectrum β-lactam hydrolyzing activity of Klebsiella pneumoniae and Escherichia coli strains isolated from clinical specimens" 29 : 477-485, 1997

80 Lee K, "Characteristics of clinical isolates of Acinetobacter genomospecies 10 carrying two different metallo-beta-lactamases" ELSEVIER 36 : 259-263, 2010

81 Papp-Wallace KM, "Carbapenems: past, present, and future" 55 : 4943-4960, 2011

82 Queenan AM, "Carbapenemases: the versatile β- lactamases" 20 : 440-458, 2007

83 Lee Y, "Carbapenem-nonsusceptible Acinetobacter baumannii of sequence type 92 or its single-locus variants with a G428T substitution in zone 2 of the rpoB gene" 66 : 66-72, 2011

84 Song W, "CTX-M-14 and CTX-M-15 enzymes are the dominant type of extended-spectrum β-lactamase in clinical isolates of Escherichia coli from Korea" 58 (58): 261-266, 2009

85 Pai H, "Association of QnrB determinants and production of extended-spectrum β-lactamases or plasmid-mediated AmpC β-lactamases in clinical isolates of Klebsiella pneumoniae" 51 : 366-368, 2007

86 Livermore DM, "Antimicrobial treatment and clinical outcome for infections with carbapenem- and multiply-resistant Acinetobacter baumannii around London" 35 : 19-24, 2010

87 Lee K, "Antimicrobial susceptibilities of bacteria isolated during 1988-1992" 158-168, 1993

88 Park SH, "Antibiotic susceptibility of pathogenic microorganisms isolated in 1969" 13 : 71-80, 1970

89 Park SJ, "Antibiotic susceptibility of clinical isolates of bacteria" 11 : 119-125, 1977

90 Bauernfeind A, "A novel type of AmpC β-lactamase, ACC-1, produced by a Klebsiella pneumoniae strain causing nosocomial pneumonia" 43 : 1924-1931, 1999

91 Pai H, "A nosocomial outbreak of Escherichia coli producing CTX-M-15 and OXA-30 β-lactamase" 27 : 312-314, 2006

92 Yum JH, "A new integron carrying VIM-2 metallo-β-lactamase gene cassette in a Serratia marcescens isolate" 42 : 217-219, 2002