We screened the major bioactive flavones isolated from Scutellaria baicalensis (baicalin, baicalein and oroxylin A) for their convulsion related activities. In electrogenic response score system and the pentylenetetrazole seizure model, baica...
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https://www.riss.kr/link?id=A107756664
Yoon, S.Y. ; dela Pena, I.C. ; Shin, C.Y. ; Son, K.H. ; Lee, Y.S. ; Ryu, J.H. ; Cheong, J.H. ; Ko, K.H.
2011
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SCOPUS,SCIE
학술저널
155-160(6쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
We screened the major bioactive flavones isolated from Scutellaria baicalensis (baicalin, baicalein and oroxylin A) for their convulsion related activities. In electrogenic response score system and the pentylenetetrazole seizure model, baica...
We screened the major bioactive flavones isolated from Scutellaria baicalensis (baicalin, baicalein and oroxylin A) for their convulsion related activities. In electrogenic response score system and the pentylenetetrazole seizure model, baicalein but not oroxylin A and baicalin exhibited anticonvulsant effects. In vitro studies also revealed that baicalein induced intracellular Cl<SUP>-</SUP> influx, whereas oroxylin A blocked muscimol- and baicalein-induced intracellular Cl<SUP>-</SUP> influx. The anticonvulsant effect of baicalein was inhibited by flumazenil, a benzodiazepine(BZD) receptor antagonist. Therefore, anticonvulsive effect of baicalein was mediated by the BZD binding site of GABA<SUB>A</SUB> receptor. The 5, 7-dihydroxyl group is present in the structure of the three flavones. It is postulated that this group played a key role in inducing convulsion-related activities.