좌식시간 변화와 고혈압 발생 위험과의 연관성: 8년 추적 코호트 자료 분석 종단 연구 = Association between Change in Sitting Time and Risk of Developing Hypertension: An 8-Year Longitudinal Follow-up Study with Cohort Data Analysis in Korea

다국어 초록 (Multilingual Abstract)

Purpose: This study aims to investigate the association between changes in sitting time based on sex and levels of physical activity participation and the risk of hypertension.
Methods: Conducted as a follow-up to the 2011-2012 baseline survey in the Korean Genome and Epidemiology Study community-based cohort study, the 4th tracking took place from 2019 to 2020 in Korea, involving adults aged 49 to 79 years. Hypertension status was determined based on systolic blood pressure ≥ 140 mm Hg, diastolic blood pressure ≥ 90 mm Hg, self-reported diagnosis, or medication usage. Change in sitting time was measured using a physical activity questionnaire. The study utilized multivariate extended Cox regression models to calculate independent risk ratios and 95% confidence intervals (CIs) for risk of developing hypertension based on change in sitting time, with a significance level set at p＜ 0.05.
Results: Despite adjusting for various factors affecting sitting time and hypertension, total sitting time (hazard ratio [HR], 1.37; 95% CI, 1.05-1.78) and weekday sitting time (HR, 1.34; 95% CI, 1.03-1.76) in the newly ST group showed increased risk of developing hypertension. It was observed that increased total and weekday sitting time in males could elevate hypertension risk (total newly ST: HR, 1.52; 95% CI, 1.05-2.21; weekday newly ST: HR, 1.57; 95% CI, 1.08-2.28). Additionally, the association between changes in sitting time and risk of developing hypertension varied based on leisure-related physical activity levels.
Conclusion: The study confirms that increased sitting time raises the risk of hypertension and that reducing sitting time in physically inactive adults can lower the risk of developing hypertension.