Ethanol의 低溫心臟에 對한 抗細動作用에 關한 硏究 = The antifibrillatory effects of ethanol on the hypothermic heart of the dogs.

다국어 초록 (Multilingual Abstract)

This experimental study was performed to clarify the antifibrillatory effects of intravenous infusion of ethanol upon hypothermic hearts. Thirty six mongrel dogs were anesthetized with thiopental sodium and were ventilated with mechanical respirator throughout the experiment. Ethanol, 2.0g/kg, diluted with 5% dextrose solution was intravenously administered in divided doses for the expermental dogs and same amount of 5% dextrose solution for control dogs. Animals were cooled with ice water and rewarmed with hot water. Heart rates and cardiac arrhythmia were checked by ECG. Central venous pressure, right ventricular and pulmonary arterial pressures were measured by means of cardiac catheterization.
Animals were divided into two groups.
Group 1.
Twenty dogs were cooled until death. Among those, 10 experimental dogs were infused ethanol intravenously.
Group 2.
Sixteen dogs were cooled down to body temperature of 20℃, when cardiac inflow and out-flow were occluded for the period of 15 minutes. Then rewarmed the animals.
The results were as follows.
1. Heart rates, arterial pressure, right ventricular and pulmonary arterial pressures were markedly decreased during the period of cooling. Ethanol infusion showed no significant influence upon those decreases.
2. Central venous pressure increased to the level of right heart failure of the cooled animal, and ethanol revealed no protective action on cardiac impairment.
3. In group 1, 10% of ventricular fibrillation was seen among the ethanol infused dogs while 30% of ventricular fibrilltion among the control group. In group 2, there was no significant difference of ventricular fibrillation between ethanol and control groups.
4. Ethanol blood level at 20℃ of body temperature was 636mg%.
5. It was suspected that ethanol failed to protect the hypothermic heart from ventricular fibrillation when cardiac inflow were occluded for the 15 minutes of period.