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      KCI등재 SCIE SCOPUS

      ML385 suppresses the proliferation, migration, and invasion of thyroid carcinoma cells by impairing aerobic glycolysis

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      https://www.riss.kr/link?id=A109283592

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      Background Current evidence shows that ML385, a new type of nuclear factor erythroid 2-related factor 2 inhibitor, exerts a good inhibitory effect on tumors. However, whether ML385 can regulate the biological behavior of thyroid cancer remains puzzling.


      Objectives We aimed to observe the regulation of ML385 on biological characteristics such as proliferation, apoptosis, migration, and invasion of thyroid tumor cells in vitro and clarify the molecular mechanism of regulating glucose metabolism of tumor cells to lay a foundation for ML385 as a therapeutic tumor drug.


      Results ML385 effectively reduced the viability, proliferation, invasion, migration, glucose consumption, lactate production, adenosine triphosphate level, and extracellular acidification rate of TPC-1 cells and concentration-dependently promoted TPC-1 cell apoptosis, indicating that ML385 inhibited the biological behavior thyroid cancer cell and aerobic glycolysis in vitro. Moreover, the above cellular behaviors were not significantly altered when 2-DG was added to ML385 treatment, suggesting that the inhibition of glycolysis by 2-DG may partially block the effect of ML385 on thyroid cancer cells.


      Conclusions ML385 inhibits the biological behavior of thyroid cancer cells by impairing aerobic glycolysis.
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      Background Current evidence shows that ML385, a new type of nuclear factor erythroid 2-related factor 2 inhibitor, exerts a good inhibitory effect on tumors. However, whether ML385 can regulate the biological behavior of thyroid cancer remains puzzlin...

      Background Current evidence shows that ML385, a new type of nuclear factor erythroid 2-related factor 2 inhibitor, exerts a good inhibitory effect on tumors. However, whether ML385 can regulate the biological behavior of thyroid cancer remains puzzling.


      Objectives We aimed to observe the regulation of ML385 on biological characteristics such as proliferation, apoptosis, migration, and invasion of thyroid tumor cells in vitro and clarify the molecular mechanism of regulating glucose metabolism of tumor cells to lay a foundation for ML385 as a therapeutic tumor drug.


      Results ML385 effectively reduced the viability, proliferation, invasion, migration, glucose consumption, lactate production, adenosine triphosphate level, and extracellular acidification rate of TPC-1 cells and concentration-dependently promoted TPC-1 cell apoptosis, indicating that ML385 inhibited the biological behavior thyroid cancer cell and aerobic glycolysis in vitro. Moreover, the above cellular behaviors were not significantly altered when 2-DG was added to ML385 treatment, suggesting that the inhibition of glycolysis by 2-DG may partially block the effect of ML385 on thyroid cancer cells.


      Conclusions ML385 inhibits the biological behavior of thyroid cancer cells by impairing aerobic glycolysis.

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      다국어 초록 (Multilingual Abstract)

      영어
      한국어
      Background Current evidence shows that ML385, a new type of nuclear factor erythroid 2-related factor 2 inhibitor, exerts a good inhibitory effect on tumors. However, whether ML385 can regulate the biological behavior of thyroid cancer remains puzzling.




      Objectives We aimed to observe the regulation of ML385 on biological characteristics such as proliferation, apoptosis, migration, and invasion of thyroid tumor cells in vitro and clarify the molecular mechanism of regulating glucose metabolism of tumor cells to lay a foundation for ML385 as a therapeutic tumor drug.




      Results ML385 effectively reduced the viability, proliferation, invasion, migration, glucose consumption, lactate production, adenosine triphosphate level, and extracellular acidification rate of TPC-1 cells and concentration-dependently promoted TPC-1 cell apoptosis, indicating that ML385 inhibited the biological behavior thyroid cancer cell and aerobic glycolysis in vitro. Moreover, the above cellular behaviors were not significantly altered when 2-DG was added to ML385 treatment, suggesting that the inhibition of glycolysis by 2-DG may partially block the effect of ML385 on thyroid cancer cells.




      Conclusions ML385 inhibits the biological behavior of thyroid cancer cells by impairing aerobic glycolysis.
      번역하기

      Background Current evidence shows that ML385, a new type of nuclear factor erythroid 2-related factor 2 inhibitor, exerts a good inhibitory effect on tumors. However, whether ML385 can regulate the biological behavior of thyroid cancer remains puzzlin...

      Background Current evidence shows that ML385, a new type of nuclear factor erythroid 2-related factor 2 inhibitor, exerts a good inhibitory effect on tumors. However, whether ML385 can regulate the biological behavior of thyroid cancer remains puzzling.




      Objectives We aimed to observe the regulation of ML385 on biological characteristics such as proliferation, apoptosis, migration, and invasion of thyroid tumor cells in vitro and clarify the molecular mechanism of regulating glucose metabolism of tumor cells to lay a foundation for ML385 as a therapeutic tumor drug.




      Results ML385 effectively reduced the viability, proliferation, invasion, migration, glucose consumption, lactate production, adenosine triphosphate level, and extracellular acidification rate of TPC-1 cells and concentration-dependently promoted TPC-1 cell apoptosis, indicating that ML385 inhibited the biological behavior thyroid cancer cell and aerobic glycolysis in vitro. Moreover, the above cellular behaviors were not significantly altered when 2-DG was added to ML385 treatment, suggesting that the inhibition of glycolysis by 2-DG may partially block the effect of ML385 on thyroid cancer cells.




      Conclusions ML385 inhibits the biological behavior of thyroid cancer cells by impairing aerobic glycolysis.

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