F-30 Prognostic impact of the Pulmonary Artery Size on Chest Computed Tomography in Idiopathic Pulmonary Fibrosis Patients = F-30 Prognostic impact of the Pulmonary Artery Size on Chest Computed Tomography in Idiopathic Pulmonary Fibrosis Patients

다국어 초록 (Multilingual Abstract)

Background: The ratio of diameter of main pulmonary artery (mPA) to the diameter of the aorta (Ao) on chest computed tomography (CT) can be related with diverse clinical conditions. We investigate the mPA/Ao ratio can associated with clinical characteristics and outcomes in idiopathic pulmonary fibrosis (IPF) patients.
Methods: In retrospective study of 303 patients with IPF at a tertiary-care center between 2011 and 2015, we reviewed the size of pulmonary artery and aorta on chest CT at initial diagnosis of IPF, including their clinical characteristics and other examinations. The primary outcomes are death or lung transplant (LTx), and the patients were followed up to June 2017.
Results: One hundred eight patients (35.64%) were died and 58 patients (19.14%) were underwent the LTx during follow up duration. The mean mPA diameter and mean Ao diameter were 28.34 mm and 34.02 mm, respectively, and the mean mPA/Ao ratio was 0.84. In total, 31 patients (10.23%) presented to the mPA/Ao ratio ＞ 1.0. The patients with mPA/Ao ratio ＞ 1.0 were associated with lower FVC, FEV1 and DLCO, and higher right ventricular pressure. In Kaplan-Meier analysis, the patients with mPA/Ao ratio ＞ 1.0 had worse outcome, including death or transplantation, than the patients with mPA/Ao ratio ≤ 1.0.
Conclusions: The mPA/Ao ratio ＞ 1.0 is related with poor functional capacity and prognosis in IPF patients.