Three‐dimensional (3D) printing has become an available technology to fabricate customized tissue engineering scaffolds with delicate architecture. This exploratory study aimed to evaluate the potential of a 3D‐printed hydroxyapatite‐based scaff...
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https://www.riss.kr/link?id=O106081391
2021년
-
0022-3492
SCI;SCIE;SCOPUS
학술저널
428-435 [※수록면이 p5 이하이면, Review, Columns, Editor's Note, Abstract 등일 경우가 있습니다.]
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
Three‐dimensional (3D) printing has become an available technology to fabricate customized tissue engineering scaffolds with delicate architecture. This exploratory study aimed to evaluate the potential of a 3D‐printed hydroxyapatite‐based scaff...
Three‐dimensional (3D) printing has become an available technology to fabricate customized tissue engineering scaffolds with delicate architecture. This exploratory study aimed to evaluate the potential of a 3D‐printed hydroxyapatite‐based scaffold as a biomaterial for obtaining guided bone regeneration (GBR) in vivo.
Scaffolds composed of 90% hydroxyapatite and 10% poly(lactic‐co‐glycolic acid) were printed using a microextrusion process to fit 4 mm diameter and 0.5 mm thick through‐and‐through osseous defects on the mandibular ramus of rats, with unfilled defects serving as controls. Specimens were analyzed for regeneration‐associated gene expression on day 7, and micro‐computed tomography (micro‐CT) and histology assessments were carried out on day 28.
The scaffolds were 3.56 ± 0.43 mm (x‐axis) and 4.02 ± 0.44 mm (y‐axis) in diameter and 0.542 ± 0.035 mm thick (z‐axis), with a mean pore size of 0.420 ± 0.028 × 0.328 ± 0.005 mm2. Most scaffolds fit the defects well. Type I collagen, VEGF, and Cbfa1 were upregulated in the scaffold‐treated defects by day 7. By day 28, de novo osteogenesis and scaffold–tissue integration were evident in the scaffold‐treated defects, and entire mineralized tissue, as well as newly formed bone, was significantly promoted, as seen in the micro‐CT and histologic analyses.
The 3D‐printed hydroxyapatite‐based scaffold showed acceptable dimensional stability and demonstrated favorable osteoregenerative capability that fulfilled the need for GBR.
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