시판중인 메트릭스 정제의 팽윤력 비교 연구 = Swelling of Commercial Matrix Tablets Based on Carboxymethyl Cellulose Sodium and Alginic Acid

다국어 초록 (Multilingual Abstract)

Alginic acid and carboxymethyl cellulose sodium are dietary fibers from plants. They have a swelling property and delay the gastric emptying time, thereby resulting in feeling satiated after oral administration, which may eventually contribute to loss of body weight. The goal of this study was to compare swelling property of three commercial matrix tablets based on alginic acid and carboxymethyl cellulose sodium. When the swelling was determined by the Korean Ministry of Food and Drug Safety (MFDS) guideline, the tablet prepared by direct compression method with highly viscous swelling agent showed the highest swelling in acidic conditions. Water uptake of these tablets was rapid and completed within 30 min. Moreover, when the pH was changed from 2.5 to 6.8 buffer, the water uptake was not significantly changed in all tablets.

목차 (Table of Contents)

• Abstract
• 실험 방법
• 결 과
• 고 찰
• 결 론
• 감사의 말씀
• References

참고문헌 (Reference)

1 Wan, L. S, "The effect of hydroxypropyl-methylcellulose on water penetration into a matrix system" 73 : 111-, 1991

2 Medarevic, D, "Polyethylene oxides as matrix forming agents: direct compression vs. wet granulation. In Proceedings of 2nd Electron" 2 : 1-, 2012

3 Du, B, "Influence of molecular weight and degree of substitution of carboxymethylcellulose on the stability of acidified milk drinks" 23 : 1420-, 2009

4 Bonferoni, M. C, "Influence of medium on dissolution-erosion behavior of Na carboxymethylcellulose and on viscoelastic properties of gels" 117 : 41-, 1995

5 Hoad, C. L, "In vivo imaging of intragastric gelation and its effect on satiety in humans" 134 : 2293-, 2004

6 Rainbird, A. L, "Effect of various types of dietary fibre on gastric emptying in growing pigs" 55 : 111-, 1986

7 "Drug Information of MALLON tablet"

8 Institute of Medicine of the National Academies, "Dietary reference intakes for energy, carbohydrates, fiber, fat, fatty acids, cholesterol, protein and amino acids" The National Academies Press 339-, 2002

9 Salvin, J. L, "Dietary fiber and body weight" 21 : 411-, 2005

10 Paxman, J. R, "Daily ingestion of alginate reduces energy intake in free-living subjects" 51 : 713-, 2008

11 Kuliche, W. M, "Characterization of aqueous carboxymethylcellulose solutions in terms of their molecular structure and its influence on rheological behavior" 37 : 2723-, 1996

12 Jensen, M. G, "Can alginatebased preloads increase weight loss beyond calorie restriction? A pilot study in obese individuals" 57 : 601-, 2011