치매노인에서 골밀도 및 혈중 지질농도와 인지기능과의 상관관계 분석 = Analysis of Correlations among Bone Mineral Density, Serum Lipid Levels, and Cognitive Function in the Elderly with Dementia

다국어 초록 (Multilingual Abstract)

Purpose The purpose of this study was to analyze the correlations among bone mineral density (BMD), serum lipid levels, and cognitive function in the elderly with dementia, Methods We recruited seventy elderly with dementia (men=35, women=35) to participate in the Korean mini mental state examination (K-MMSE). Their T-scores and serum lipid levels were analyzed for correlation analysis, Results The results of this study showed that there are significant correlations between cognitive function and three factors BMD, low-density lipoprotein cholesterol (LDL-C) level, and total cholesterol (TC) level, The cognitive function scores increased proportionally with BMD but were inversely proportional to LDL-C and TC levels. There were no significant relations among cognitive function, high-density lipoprotein cholesterol (HDL-C) level, and triglyceride (TG) level. Conclusion These results indicate that there is a direct proportionality between cognitive function and BMD and inverse proportionalities between cognitive function and LDL-C level and between cognitive function and TC level. Therefore, these levels can be indices for preventing and predicting dementia.

참고문헌 (Reference)

1 강연욱, "치매노인들을 대상으로 한K-MMSE의 타당도 연구" 15 (15): 300-308, 1997

2 서울대학교병원, "치매 노인 유병율 조사" 2008

3 보건복지부, "전국 노인 인지장애 유병율 조사 보고서" 2008

4 질병관리본부, "인지기능장애와 골밀도와의 연관성 고찰: 지역사회 노인코호트 조사결과, 2006-2007" 2 (2): 669-672, 2009

5 김희진, "알츠하이머병 환자에서의 삶의 질 평가" 대한신경과학회 26 (26): 308-313, 2008

6 김동현, "도시지역 노인들의 치매 유병률에 관한 단면조사연구" 32 (32): 303-316, 1999

7 윤성욱, "노인인구에서 인지기능과 혈청지질농도의 연관성" 대한신경정신의학회 48 (48): 429-435, 2009

8 유영선, "노인 인구에서 신경인지기능저하와 혈청 지질농도와의 상관성" 대한신경정신의학회 47 (47): 540-547, 2008

9 김덕윤, "골밀도 측정의 올바른 임상 적용" 대한핵의학회 38 (38): 275-281, 2004

10 김태현, "경도인지장애 노인군에서 APOE ε4와 지질농도가 인지기능에 미치는 영향" 건국대학교 대학원 2010

11 Folstein MF, "“Minimental state”: A practical method for grading the cognitive state of patients for the clinician" 12 (12): 189-198, 1975

12 Kivipelto M, "Vascular risk factors and late-life mild cognitive impairment: A population-based study" 56 (56): 1683-1689, 2001

13 Ruben DB, "The predictive value of combined hypoalbuminemia and hypocholesterolemia in high functioning communitydwelling older persons: MacArthur Studies of Successful Aging" 47 (47): 402-406, 1999

14 Razay G, "The Metabolic syndrome and Alzheimer Disease" 64 (64): 93-96, 2007

15 Yaffe K, "Serum lipoprotein levels, statin use, and cognitive function in older women" 59 (59): 378-384, 2002

16 Solomon A, "Serum cholesterol changes after midlife and late-life cognition: Twenty-one-year follow-up study" 68 (68): 751-756, 2007

17 Li G, "Serum Cholesterol and risk of Alzheimer disease: a communitybased cohort study" 65 (65): 1045-1050, 2005

18 Suh GH, "Prevalence and risk factors of dementia depression in the elderly" 39 (39): 809-824, 2000

19 Merched A, "Decreased high-density lipoprotein cholesterol and serum apolipoprotein AI concentrations are highly correlated with the severity of Alzheimer's Disease" 21 (21): 27-30, 2000

20 Li L, "Cognitive performance and plasma levels of homocysteine, vitamin B12, folate and lipids in patients with Alzheimer disease" 26 (26): 384-390, 2008

21 Dietschy JM, "Cholesterol metabolism in the brain" 12 (12): 105-112, 2001

22 Michikawa M, "Cholesterol Paradox: is high total or low HDL cholesterol level a risk for Alzheimer's disease?" 72 (72): 141-146, 2003

23 Tan ZS, "Bone Mineral Density and the Risk of Alzheimer Disease" 62 (62): 107-111, 2005

24 Lui LY, "Bone Loss Predicts Subsequent Cognitive Decline in Older Women: The Study of Osteoporotic Fractures" 51 (51): 38-43, 2003

25 Isbir T, "Apolipoprotein-E gene polymorphism and lipid profiles in Alzheimer disease" 16 (16): 77-81, 2001