당뇨병환자에서의 인공취도를 이용한 Insulin 요구를 측정 = Determination of 24 - Hour lnsulin Requirement Using Artificial Beta Cell ( Biostator(R) ) in Diabetic Patients

다국어 초록 (Multilingual Abstract)

Blood glucose and insulin profile were observed on 4 IDDM and 5 NIDDM patients under feedback control with artificial beta cell. The results were as follows; 1) The daily glucose profile was quickly normalized in insulin requiring diabetics under feedback control with artificial panceras. 2) During feedback control, the mean total daily insulin requirement (42.3 U in IDDM, 69,6 U in NIDDM) to normalize blood glucose profile was more than that used in conventional therapy (40.5 U in IDDM, 50.8 U in NIDDM) and it was significantly correlated to glycosylated hemoglobin concentration before feedback control but not to the duration of diabetes or prior insulin treatment. 3) Comparing with conventional therapy, larger amount of short acting insulin (4.5% to 34% in IDDM, 6.0% to 43.2% in N1DI>M) was necessary to maintain normal blood glucose profile with new insulin regimen based on the results from artificial beta cell. 4) The insulin requirement after breakfast was more than that of lunch or supper, and it could be reflected to higher cortisol concentration before breakfast, These results suggest that artificial beta cell would be a beneficial tool for rapid control of blood glucose and measuring the insulin requirement in diabetic patients