Mizoribine 사용 후 발생한 수족 증후군 = Short Report : Mizoribine Induced Hand-Foot Syndrome

다국어 초록 (Multilingual Abstract)

Hand-foot syndrome is also known as palmar-plantar erythrodysesthesia, and it is a side effect that mostly occurs with chemotherapy or biologic therapy. It is characterized by a painful erythema and edema, which may be followed by dry or moist desquamation of the palms and soles. Mizoribine (MZR) is an imidazole nucleoside that blocks purine biosynthesis. It was found to inhibit both humoral and cellular immunity by selectively inhibiting proliferation of lymphocytes. MZR has been used for preventing renal transplant rejection and treating rheumatoid arthritis, nephritic syndrome and lupus nephritis. The principal adverse reactions are leukopenia, abnormal hepatic function and hyperuricemia. The cutaneous side effects are skin rash, prurigo and epilation, with an incidence of about 1.32%, 0.77% and 0.55%, respectively. To the best of our knowledge, no case of hand-foot syndrome associated with MZR has ever been published. Herein, we report that MZR, which has been widely used, may induce drug-induced hand-foot syndrome. (Korean J Dermatol 2010;48(7):642∼645)

참고문헌 (Reference)

1 Fitzpatrick JE, "The cutaneous histopathology of chemotherapeutic reactions" 20 : 1-14, 1993

2 Mizuno K, "Studies on bredinin:I.isolation,characterization and biological properties" 27 : 775-782, 1974

3 Matsushita K, "Stevens-Johnson syndrome induced by mizoribine in a patient with systemic lupus erythematosus" 16 : 113-116, 2006

4 Susser WS, "Mucocutaneous reactions to chemotherapy" 40 : 367-398, 1999

5 Kawasaki Y, "Mizoribine:A new approach in the treatment of renal disease" 2009 : 681482-, 2009

6 Takei S, "Mizoribine in the treatment of rheumatoid arthritis and juvenile idiopathic arthritis" 44 : 205-209, 2002

7 Yoshizawa M, "Immunosuppressive effect of mizoribine:I.effect on immune response cells" 14 : 256-262, 1982

8 Yoshizawa M, "Immunosuppressive effect of mizoribine: II. Suppression of humoral and cellular immune response" 14 : 561-570, 1982

9 Tsai KY, "Handfoot syndrome and seborrheic dermatitis-like rash induced by sunitinib in a patient with advanced renal cell carcinoma" 24 : 5786-5788, 2006

10 Nagore E, "Antineoplastic therapyinduced palmar plantar erythrodysesthesia(‘hand-foot’)syndrome.Incidence,recognition and management" 1 : 225-234, 2000