인체의 일주기리듬 = Human Circadian Rhythms

다국어 초록 (Multilingual Abstract)

A 'circadian rhythm' is a self-sustained biological rhythm (cycle) that repeats itself approximately every 24 hours. Circadian rhythms are generated by an internal clock, or pacemaker, and persist even in the absence of environmental time cues, collectively termed 'zeitgebers.' Although organisms generate circadian rhythms internally, they are entrained by environmental stimuli, particularly the light-dark cycle. Measurement of the endogenous melatonin rhythm provides relatively reliable surrogate way of assessing the timing of the internal circadian clock. Also, core body temperature and cortisol can be used as markers of circadian rhythms. The sleep-wake cycle, body temperature, and melatonin rhythm have a stable internal phase relationship in humans and other diurnal species. They play an important role in controlling daily behavioral rhythms including task performance, blood pressure, and synthesis and secretion of several hormones. In this review, we address not only the properties, methods of measurement, and markers of circadian rhythms, but also the physiological and psychological importance of human circadian rhythms.

참고문헌 (Reference)

1 김민균, "주기적 리듬 조절에 의한 멜라토닌 생산과 생리적 기능의 중요성" 한국생명과학회 23 (23): 1064-1072, 2013

2 Liu X, "circadian sleep propensity and melatonin rhythm in healthy human subjects" 280 : 199-202, 2000

3 Van Cauter E, "al. Simultaneous stimulation of slow-wave sleep and growth hormone secretion by gamma-hydroxybutyrate in normal young Men" 100 : 745-, 1997

4 Farhy LS, "Unequal autonegative feedback by GH models the sexual dimorphism in GH secretory dynamics" 282 : R753-R764, 2002

5 Leproult R, "Transition from Dim to Bright Light in the Morning Induces an Immediate Elevation of Cortisol Levels 1" 86 : 151-157, 2001

6 Kraemer S, "Time-of-day variations of indicators of attention: performance, physiologic parameters, and self-assessment of sleepiness" 48 : 1069-1080, 2000

7 Weibel L, "The start of the quiescent period of cortisol remains phase locked to the melatonin onset despite circadian phase alterations in humans working the night schedule" 318 : 89-92, 2002

8 Lack L, "The rhythms of human sleep propensity and core body temperature" 5 : 1-11, 1996

9 Hébert M, "The effects of prior light history on the suppression of melatonin by light in humans" 33 : 198-203, 2002

10 Ahlersova E, "The effect of various photoperiods on daily oscillations of serum corticosterone and insulin in rats" 41 : 315-321, 1991

11 Richard D, "The corticotropin-releasing hormone system in the regulation of energy balance in obesity" 24 : S36-S39, 2000

12 Leproult R, "Sleepiness, performance, and neuroendocrine function during sleep deprivation: effects of exposure to bright light or exercise" 12 : 245-258, 1997

13 Moller HJ, "Sleepiness is not the inverse of alertness: evidence from four sleep disorder patient groups" 173 : 258-266, 2006

14 Carskadon MA, "Sleepiness and sleep state on a 90-min schedule" 14 : 127-133, 1977

15 Lavie P, "Sleep-wake as a biological rhythm" 52 : 277-303, 2001

16 Copinschi G, "Sleep and hormonal changes in aging" 42 : 371-389, 2013

17 Zeitzer JM, "Sensitivity of the human circadian pacemaker to nocturnal light: melatonin phase resetting and suppression" 526 : 695-702, 2000

18 Horowitz TS, "Searching night and day: a dissociation of effects of circadian phase and time awake on visual selective attention and vigilance" 14 : 549-557, 2003

19 Boivin DB, "Resetting of circadian melatonin and cortisol rhythms in humans by ordinary room light" 9 : 779-782, 1998

20 Wright Jr KP, "Relationship between alertness, performance, and body temperature in humans" 283 : R1370-R1377, 2002

21 Gillberg M, "Relations between performance and subjective ratings of sleepiness during a night awake" 17 : 236-241, 1994

22 Sayers G, "Regulation of pituitary adrenocorticotrophic activity during the response of the rat to acute stress 1" 40 : 265-273, 1947

23 Farhy LS, "Putative GH pulse renewal: periventricular somatostatinergic control of an arcuate-nuclear somatostatin and GH-releasing hormone oscillator" 286 : R1030-R1042, 2004

24 Lefebvre P, "Pulsatility of insulin and glucagon release: physiological significance and pharmacological implications" 30 : 443-452, 1987

25 Gronfier C, "Pulsatile cortisol secretion and EEG delta waves are controlled by two independent but synchronized generators" 275 : E94-E100, 1998

26 Mehta S, "Prolactin and cortisol levels in seizure disorders" 42 : 709-712, 1994

27 Anderson L, "Physiology of ghrelin and related peptides" 29 : 111-144, 2005

28 Brabant G, "Physiological Regulation of Circadian and Pulsatile Thyrotropin Secretion in Normal Man and Woman" 70 : 403-409, 1990

29 Baigent S, "Peripheral corticotropin-releasing hormone and urocortin in the control of the immune response" 22 : 809-820, 2001

30 Samuels M, "Patterns of Pulsatile Pituitary Glycoprotein Secretion in Central Hypothyroidism and Hypogonadism" 70 : 391-395, 1990

31 Giustina A, "Pathophysiology of the Neuroregulation of Growth Hormone Secretion in Experimental Animals and the Human 1" 19 : 717-797, 1998

32 Dijk DJ, "Paradoxical timing of the circadian rhythm of sleep propensity serves to consolidate sleep and wakefulness in humans" 166 : 63-68, 1994

33 Ceresa F, "Once-a-day neurally stimulated and basal ACTH secretion phases in man and their response to corticoid inhibition" 29 : 1074-1082, 1969

34 Ebadi M, "Neural pathways and neurotransmitters affecting melatonin synthesis" 21 : 125-155, 1985

35 Vgontzas AN, "Middle-aged men show higher sensitivity of sleep to the arousing effects of corticotropin-releasing hormone than young men: clinical implications" 86 : 1489-1495, 2001

36 Shibui K, "Melatonin rhythms in delayed sleep phase syndrome" 14 : 72-76, 1999

37 Scheer F, "Light affects morning salivary cortisol in humans" 84 : 3395-3398, 1999

38 Shanahan TL, "Light Exposure Induces Equivalent Phase Shifts of the Endogenous Circadian Rhythms of Circulating Plasma Melatonin and Core Body Temperature in Men" 73 : 227-235, 1991

39 Farhy LS, "Joint pituitary-hypothalamic and intrahypothalamic autofeedback construct of pulsatile growth hormone secretion" 285 : R1240-R1249, 2003

40 American Academy of Sleep Medicine, "International Classification of Sleep Disorders, Third Edition: Diagnostic and Coding Manual, Westchester, Ill"

41 Frey DJ, "Inter- and intra-individual variability in performance near the circadian nadir during sleep deprivation" 13 : 305-315, 2004

42 Leproult R, "Individual differences in subjective and objective alertness during sleep deprivation are stable and unrelated" 284 : R280-R290, 2003

43 Spiegel K, "Impact of sleep debt on metabolic and endocrine function" 354 : 1435-1439, 1999

44 Wennink JM, "Growth hormone secretion patterns in relation to LH and testosterone secretion th-roughout normal male puberty" 123 : 263-270, 1990

45 Wennink JM, "Growth hormone secretion patterns in relation to LH and estradiol secretion throughout normal female puberty" 124 : 129-135, 1991

46 Waldstreicher J, "Gender differences in the temporal organization of proclactin (PRL) secretion: evidence for a sleep-independent circadian rhythm of circulating PRL levels-a clinical research center study" 81 : 1483-1487, 1996

47 Rao M, "Epileptic but not psychogenic seizures are accompanied by simultaneous elevation of serum pituitary hormones and cortisol levels" 49 : 33-39, 1989

48 Skene DJ, "Effects of light on human circadian rhythms" 39 : 295-304, 1999

49 Van Cauter E, "Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol" 81 : 2468-2473, 1996

50 Kim WJ, "Effect of Disrupted Diurnal Changes on Circadian Clock and Hormonal System: Adverse Health Consequences and Diabetes" 22 : 23-29, 2012

51 Beck-Nielsen H, "Diurnal Variation in Insulin Binding to Human Monocytes" 47 : 385-390, 1978

52 Van Pett K, "Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse" 428 : 191-212, 2000

53 Fabbian F, "Dipper and non-dipper blood pressure 24-hour patterns: circadian rhythm-dependent physiologic and pathophysiologic mechanisms" 30 : 17-30, 2013

54 Verrillo A, "Differential roles of splanchnic and peripheral tissues in determining diurnal fluctuation of glucose tolerance" 257 : E459-, 1989

55 Childs GV, "Differential Expression of Growth Hormone Messenger Ribonucleic Acid by Somatotropes and Gonadotropes in Male and Cycling Female Rats 1" 141 : 1560-1570, 2000

56 Caufriez A, "Copinschi G. Immediate effects of an 8-h advance shift of the rest-activity cycle on 24-h profiles of cortisol" 282 : E1147-E1153, 2002

57 Dijk DJ, "Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans" 15 : 3526-3538, 1995

58 Strogatz S, "Circadian wake maintenance zones and insomnia in man" 14 : 219-, 1985

59 Feuers R, "Circadian stage dependent 125I-insulin binding in the liver and epididymal fat of the mouse" 341 : 529-, 1990

60 Carrier J, "Circadian rhythms of performance: new trends" 17 : 719-732, 2000

61 Strogatz SH, "Circadian regulation dominates homeostatic control of sleep length and prior wake length in humans" 9 : 353-364, 1986

62 Strogatz SH, "Circadian pacemaker interferes with sleep onset at specific times each day: role in insomnia" 135 : 179-, 1987

63 Dijk DJ, "Circadian and sleep/wake dependent aspects of subjective alertness and cognitive performance" 1 : 112-117, 1992

64 Kim SH, "Circadian and seasonal variations of ventricular tachyarrhythmias in patients with early repolarization syndrome and Brugada syndrome: analysis of patients with implantable cardioverter defibrillator" 23 : 757-763, 2012

65 Behrends J, "Central nervous system control of thyrotropin secretion during sleep and wakefulness" 49 : 173-177, 1998

66 Czeisler C, "Association of sleep-wake habits in older people with changes in output of circadian pacemaker" 340 : 933-936, 1992

67 Smith KA, "Adaptation of human pineal melatonin suppression by recent photic history" 89 : 3610-3614, 2004

68 Muzet A, "A quantitative evaluation of the relationships between growth hormone secretion and delta wave electroencephalographic activity during normal sleep and after enrichment in delta waves" 19 : 817-824, 1996

69 Khalsa SBS, "A phase response curve to single bright light pulses in human subjects" 549 : 945-952, 2003

70 Monk TH, "A parallelism between human body temperature and performance independent of the endogenous circadian pacemaker" 13 : 113-122, 1998

71 Berman N, "A mathematical model of oscillatory insulin secretion" 264 : R839-R839, 1993