40세 이상 건강한 성인에서 시간에 따른 체지방량과 복부지방률 변화가 폐기능 감소에 미치는 영향 = The effect of changes in total body fat amount and abdominal fat ratio on lung function decline in healthy adults

다국어 초록 (Multilingual Abstract)

Purpose: Many studies have shown that obesity is one of the major causes of lung function decline. However, a longitudinal study of the correlation between changes in obesity degree and lung function is still lacking. This study aimed to analyze alterations in lung function according to changes in body and abdominal fat amount over time in healthy individuals.
Methods: A retrospective cohort study of individuals who received annual health screening was performed. Individuals who underwent health screening at least 3 times with follow-up periods more than 5 years were included. Using a linear mixed model, we analyzed associations between the change in total body fat amount/abdominal fat ratio and lung function decline over time by dividing each quartile according to the fat change rate.
Results: A total of 15,484 individuals over 40 years old was enrolled prospectively. A longitudinal increase in total body fat amount over time was associated with a predicted value of forced expiratory volume in 1 second (FEV₁p; %) and predicted value of forced vital capacity (FVCp; %) declines, regardless of sex. A similar phenomenon was observed between an increase in abdominal fat ratio and FEV₁p/FVCp decline, which was predominant in males. In addition, the change in abdominal fat ratio showed a significant correlation with differences in the initial values of FEV₁p and FVCp after 40 years old.
Conclusion: Increases in total body fat amount and abdominal fat ratio may cause lung function decline over time. (Allergy Asthma Respir Dis 2021;9:171-179)

참고문헌 (Reference)

1 최정근, "한국인의 정상 폐활량 예측치" 대한결핵및호흡기학회 58 (58): 230-242, 2005

2 전해옥, "한국 노인의 성별에 따른 복부비만에 영향을 주는 요인: 건강 및 건강행태 관련 요인을 중심으로" 한국산학기술학회 19 (19): 559-568, 2018

3 김상하, "성인 천식 환자에서 성별에 따른 비만과 기도과민성과의 관련성" 대한 소아알레르기 호흡기학회 2 (2): 1-2, 2014

4 정승교, "성인 여성의 비만이 폐기능에 미치는 영향 - 체질량지수와 허리둘레 기준 -" 한국보건간호학회 28 (28): 22-31, 2014

5 Organization WH, "Waist circumference and waist-hip ratio: report of a WHO expert consultation" World Health Organization

6 Malli F, "The role of leptin in the respiratory system : an overview" 11 : 1-16, 2010

7 박정은, "The Effect of Body Composition on Pulmonary Function" 대한결핵및호흡기학회 72 (72): 433-440, 2012

8 Kotani K, "Sexual dimorphism of age-related changes in whole-body fat distribution in the obese" 18 : 207-202, 1994

9 De Souza SAF, "Role of body mass index in pulmonary function of morbidly obese subjects" 132 (132): 613C-, 2007

10 Bates DV, "Respiratory function in disease" Saunders 1989

11 Staiger H, "Relationship of serum adiponectin and leptin concentrations with body fat distribution in humans" 11 : 368-376, 2003

12 Park CH, "Relationship between skeletal muscle mass and lung function in Korean adults without clinically apparent lung disease" 97 : e12281-, 2018

13 서미혜, "Prevalence of Obesity and Incidence of Obesity-Related Comorbidities in Koreans Based on National Health Insurance Service Health Checkup Data 2006–2015" 대한비만학회 27 (27): 46-52, 2018

14 Forno E, "Overweight, obesity, and lung function in children and adults—a meta-analysis" 6 : 570-581, 2018

15 Beuther DA, "Overweight, obesity, and incident asthma : a meta-analysis of prospective epidemiologic studies" 175 : 661-666, 2007

16 Gibeon D, "Obesity-associated severe asthma represents a distinct clinical phenotype : analysis of the British Thoracic Society Difficult Asthma Registry Patient cohort according to BMI" 143 : 406-414, 2013

17 Farah CS, "Obesity is a determinant of asthma control independent of inflammation and lung mechanics" 140 : 659-666, 2011

18 Rönmark E, "Obesity increases the risk of incident asthma among adults" 25 : 282-288, 2005

19 Sue DY, "Obesity and pulmonary function : more or less" 111 : 844-846, 1997

20 Friedman J, "Leptin at 20 : an overview" 223 : T1-T8, 2014

21 Pellegrino R, "Interpretative strategies for lung function tests" 26 : 948-968, 2005

22 Arteaga-Solis E, "Inhibition of leptin regulation of parasympathetic signaling as a cause of extreme body weight-associated asthma" 17 : 35-48, 2013

23 Sin DD, "Impaired lung function and serum leptin in men and women with normal body weight : a population based study" 58 : 695-698, 2003

24 Croteau-Chonka DC, "Gene coexpression networks in whole blood implicate multiple interrelated molecular pathways in obesity in people with asthma" 26 : 1938-1948, 2018

25 Seidell J, "Fat distribution in European men : a comparison of anthropometric measurements in relation to cardiovascular risk factors" 16 : 17-22, 1992

26 Lazarus R, "Effects of body composition and fat distribution on ventilatory function in adults" 68 : 35-41, 1998

27 Harris RB, "Direct and indirect effects of leptin on adipocyte metabolism" 1842 : 414-423, 2014

28 Tantisira K, "Complex interactions in complex traits: obesity and asthma" 56 : ii64-ii74, 2001

29 Permaul P, "Childhood asthma and obesity—what is the true link?" 113 : 244-246, 2014

30 Sutherland ER, "Body mass index and phenotype in subjects with mild-to-moderate persistent asthma" 123 : 1328-1334, 2009

31 Allison DB, "Annual deaths attributable to obesity in the United States" 282 : 1530-1538, 1999

32 Kwon JW, "Airway hyperresponsiveness is negatively associated with obesity or overweight status in patients with asthma" 159 : 187-193, 2012

33 Pascot A, "Age-related increase in visceral adipose tissue and body fat and the metabolic risk profile of premenopausal women" 22 : 1471-1478, 1999

34 Kern PA, "Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance" 280 : E745-E751, 2001

35 Sood A, "Adiponectin, leptin, and resistin in asthma : basic mechanisms through population studies" 2013 : 785835-, 2013

36 Canoy D, "Abdominal obesity and respiratory function in men and women in the EPIC-Norfolk Study, United Kingdom" 159 : 1140-1149, 2004

37 Ryan AS, "A cross-sectional study on body composition and energy expenditure in women athletes during aging" 271 : E916-E921, 1996

38 김성열, "40대 여성에서 체지방률과 체질량지수가 폐기능에 미치는 영향" 대한가정의학회 24 (24): 8-832, 2003

39 서미혜, "2018 Korean Society for the Study of Obesity Guideline for the Management of Obesity in Korea" 대한비만학회 28 (28): 40-45, 2019