Plastic changes of motor network after constraint-induced movement therapy

다국어 초록 (Multilingual Abstract)

The effects of short-term constraint-induced movement (CIM) therapy on the activation of the motor network were investigated with functional magnetic resonance imaging (fMRI). Movement of the less-affected arms of five patients was restricted and intensive training of the affected upper limb was performed. Functional MRI was acquired before and after two-weeks of CIM therapy. All patients showed significant improvement of motor function in their paretic limbs after CIM therapy. For three patients, new activation in the contralateral motor/premotor cortices was observed after CIM therapy. Increased activation of the ipsilateral motor cortex and SMA was observed in the other patient. Our results demonstrated that plastic changes of the motor network occurred as a neural basis of the improvement subsequent to CIM therapy following brain injury.

참고문헌 (Reference)

1 "Sensory maps in the human brain" 368 : 592-593, 1994

2 "Progressive improvement in discriminative abilities in adult owl monkeys performing a tactile frequency discrimination task" 67 : 1015-1030, 1992

3 "Plasticity in the motor system related to therapy-induced improvement of movement after stroke" 10 : 807-810, 1999

4 "Motor cortex plasticity during constraint-induced movement therapy in stroke patients" 250 : 5-8, 1998

5 "Massive cortical reorganization after sensory deafferentation in adult macaques" 252 : 1857-1860, 1991

6 "Increased use of the left hand in string players associated with increased cortical representation of the fingers" 220 : 21-23, 1995

7 "Improved motor recovery after stroke and massive cortical reorganization following constrain-induced movement therapy" 14 : S77-S91, 2003

8 "Functional reorganization of primary somatosensory cortex in adult owl monkeys after behaviorally controlled tactile stimulation" 63 : 82-104, 1990

9 "Functional MRI evidence of cortical reorganization in upper-limb stroke hemiparesis treated with constraint-induced movement therapy" 80 : 4-12, 2001

10 "Extensive reorganization of the somatosensory cortex in adult humans after nervous system injury" 5 : 2593-2597, 1994

11 "Effects of constraint-induced movement therapy on patients with chronic motor deficits after stroke" 30 : 586-592, 1999

12 "Correlation between motor improvements and altered fMRI activity after rehabilitative therapy" 125 : 2731-2742, 2002

13 "Constraint-induced movement therapy: A new approach to treatment in physical rehabilitation" 43 : 152-170, 1998

14 "Constraint-induced movement therapy for motor recovery in chronic stroke patients" 80 : 624-628, 1999

15 "Constraint-induced motor relearning after stroke: a naturalistic case report" 82 : 524-528, 2001

16 "Constraint-Induced Movement Therapy: A new family of techniques with broad application to physical rehabilitation-a clinical review" 36 : 238-251, 1999

17 "Changed perceptions in Braille readers" 391 : 134-135, 1998

18 "An application of upper-extremity constraint-induced movement therapy in a patient with subacute stroke" 79 : 847-853, 1999

19 "A functional MRI study of subjects recovered from hemiparetic stroke" 28 : 2518-2527, 1997