Revisiting Rupture of Benign Thyroid Nodules after Radiofrequency Ablation: Various Types and Imaging Features

다국어 초록 (Multilingual Abstract)

Background: To evaluate the imaging features, clinical manifestations, and prognosis of patients with thyroid nodule rupture afterradiofrequency ablation (RFA).
Methods: The records of 12 patients who experienced thyroid nodule rupture after RFA at four Korean thyroid centers betweenMarch 2010 and July 2017 were retrospectively reviewed. Clinical data evaluated included baseline patient characteristics, treatmentmethods, initial presenting symptoms, imaging features, treatment, and prognosis.
Results: The most common symptoms of post-RFA nodule rupture were sudden neck bulging and pain. Based on imaging features,the localization of nodule rupture was classified into three types: anterior, posterolateral, and medial types. The anterior type is themost often, followed by posterolateral and medial type. Eight patients recovered completely after conservative treatment. Four patientswho did not improve with conservative management required invasive procedures, including incision and drainage or aspiration.
Conclusion: Thyroid nodule rupture after RFA can be classified into three types based on its localization: anterior, posterolateral,and medial types. Because majority of thyroid nodule ruptures after RFA can be managed conservatively, familiarity with these imaging features is essential in avoiding unnecessary imaging workup or invasive procedures.

참고문헌 (Reference)

1 하은주, "Ultrasonography-Based Thyroidal and Perithyroidal Anatomy and Its Clinical Significance" 대한영상의학회 16 (16): 749-766, 2015

2 신정희, "Ultrasonography Diagnosis and Imaging-Based Management of Thyroid Nodules: Revised Korean Society of Thyroid Radiology Consensus Statement and Recommendations" 대한영상의학회 17 (17): 370-395, 2016

3 Deandrea M, "US-guided percutaneous radiofrequency thermal ablation for the treatment of solid benign hyperfunctioning or compressive thyroid nodules" 34 : 784-791, 2008

4 Che Y, "Treatment of benign thyroid nodules : comparison of surgery with radiofrequency ablation" 36 : 1321-1325, 2015

5 Spiezia S, "Thyroid nodules and related symptoms are stably controlled two years after radiofrequency thermal ablation" 19 : 219-225, 2009

6 박혜선, "Thyroid Radiofrequency Ablation: Updates on Innovative Devices and Techniques" 대한영상의학회 18 (18): 615-623, 2017

7 Chung SR, "Safety of radiofrequency ablation of benign thyroid nodules and recurrent thyroid cancers : a systematic review and meta-analysis" 33 : 920-930, 2017

8 Shin JH, "Rupture of benign thyroid tumors after radio-frequency ablation" 32 : 2165-2169, 2011

9 Lee JH, "Radiofrequency ablation(RFA)of benign thyroid nodules in patients with incompletely resolved clinical problems after ethanol ablation(EA)" 34 : 1488-1493, 2010

10 Jeong WK, "Radiofrequency ablation of benign thyroid nodules : safety and imaging follow-up in 236 patients" 18 : 1244-1250, 2008

11 Sim JS, "Radiofrequency ablation of benign thyroid nodules : depicting early sign of regrowth by calculating vital volume" 33 : 905-910, 2017

12 Lim HK, "Radiofrequency ablation of benign non-functioning thyroid nodules : 4-year follow-up results for 111 patients" 23 : 1044-1049, 2013

13 Kim YS, "Radiofrequency ablation of benign cold thyroid nodules : initial clinical experience" 16 : 361-367, 2006

14 Hong MJ, "Radiofrequency ablation is a thyroid function-preserving treatment for patients with bilateral benign thyroid nodules" 26 : 55-61, 2015

15 Baek JH, "Radiofrequency ablation for the treatment of autonomously functioning thyroid nodules" 33 : 1971-1977, 2009

16 Bernardi S, "Radiofrequency ablation compared to surgery for the treatment of benign thyroid nodules" 2014 : 934595-, 2014

17 Valcavi R, "Percutaneous laser ablation of cold benign thyroid nodules : a 3-year follow-up study in 122 patients" 20 : 1253-1261, 2010

18 Baek JH, "Locoregional control of metastatic well-differentiated thyroid cancer by ultrasound-guided radiofrequency ablation" 197 : W331-W336, 2011

19 박혜선, "Innovative Techniques for Image-Guided Ablation of Benign Thyroid Nodules: Combined Ethanol and Radiofrequency Ablation" 대한영상의학회 18 (18): 461-469, 2017

20 Guenette JP, "Image-guided ablation of postsurgical locoregional recurrence of biopsy-proven well-differentiated thyroid carcinoma" 24 : 672-679, 2013

21 Valcavi R, "Health-related quality of life after percutaneous radiofrequency ablation of cold, solid, benign thyroid nodules: a 2-year follow-up study in 40 patients" 21 : 887-896, 2015

22 Kim JH, "Efficacy and safety of radiofrequency ablation for treatment of locally recurrent thyroid cancers smaller than 2 cm" 276 : 909-918, 2015

23 백정환, "Current status of core needle biopsy of the thyroid" 대한초음파의학회 36 (36): 83-85, 2017

24 나동규, "Core Needle Biopsy of the Thyroid: 2016 Consensus Statement and Recommendations from Korean Society of Thyroid Radiology" 대한영상의학회 18 (18): 217-237, 2017

25 Wang JF, "Complications following radiofrequency ablation of benign thyroid nodules : a systematic review" 130 : 1361-1370, 2017

26 Baek JH, "Complications encountered in the treatment of benign thyroid nodules with US-guided radiofrequency ablation : a multicenter study" 262 : 335-342, 2012

27 Ha EJ, "Comparative efficacy of radiofrequency and laser ablation for the treatment of benign thyroid nodules : systematic review including traditional pooling and Bayesian network meta-analysis" 100 : 1903-1911, 2015

28 Baek JH, "Benign predominantly solid thyroid nodules : prospective study of efficacy of sonographically guided radiofrequency ablation versus control condition" 194 : 1137-1142, 2010

29 김지훈, "2017 Thyroid Radiofrequency Ablation Guideline: Korean Society of Thyroid Radiology" 대한영상의학회 19 (19): 632-655, 2018