Association between Serum Gamma-Glutamyltransferase and Prevalence of Metabolic Syndrome Using Data from the Korean Genome and Epidemiology Study

다국어 초록 (Multilingual Abstract)

Background: The aim of this study was to determine whether there is a positive correlation between gamma-glutamyltransferase(GGT) levels and the prevalence of metabolic syndrome and whether GGT can be used as an easily checkable metabolic index usingdata from the large-scale Korean Genome and Epidemiology Study (KoGES).
Methods: We obtained data of 211,725 participants of the KoGES. The collected data included age, sex, height, weight, waist circumference, and various biochemical characteristics, including serum GGT levels. The data of study participants who ingested morethan 40 g/day of alcohol and who were diagnosed with metabolic syndrome at baseline was excluded. We analyzed the prevalence ofmetabolic syndrome according to GGT quartiles in both genders.
Results: The GGT level was significantly higher in subjects with metabolic syndrome compared to normal subjects (37.92±48.20mg/dL vs. 25.62±33.56 mg/dL). The prevalence of metabolic syndrome showed a stepwise increase with GGT quartiles in bothmale and female subjects. Compared to the lowest GGT quartile, the odds ratio was 1.534 (95% confidence interval [CI], 1.432 to1.643), 1.939 (95% CI, 1.811 to 2.076), and 2.754 (95% CI, 2.572 to 2.948) in men and 1.155 (95% CI, 1.094 to 1.218), 1.528 (95%CI, 1.451 to 1.609), and 2.022 (95% CI, 1.921 to 2.218) in women with increasing GGT quartile. The cutoff value of GGT predictingrisk of metabolic syndrome was 27 IU/L in men and 17 IU/L in women.
Conclusion: We suggested that GGT could be an easily checkable marker for the prediction of metabolic syndrome.

참고문헌 (Reference)

1 이미영, "혈청 감마지티(gamma-glutamyltransferase)와 당뇨병 유병률과의 상관관계" 대한내과학회 67 (67): 498-505, 2004

2 Banderas DZ, "γ-Glutamyl transferase : a marker of nonalcoholic fatty liver disease in patients with the metabolic syndrome" 24 : 805-810, 2012

3 Ahn Y, "Validation and reproducibility of food frequency questionnaire for Korean genome epidemiologic study" 61 : 1435-1441, 2007

4 Lee JH, "The association of metabolic syndrome and serum γ-glutamyl transpeptidase: a 4-year cohort study of 3,698 Korean male workers" 2 : 67-75, 2013

5 Breitling LP, "Synergism between smoking and alcohol consumption with respect to serum gamma-glutamyltransferase" 49 : 802-808, 2009

6 Kim DJ, "Serum gamma-glutamyltransferase within its normal concentration range is related to the presence of diabetes and cardiovascular risk factors" 22 : 1134-1140, 2005

7 Nakanishi N, "Serum gamma-glutamyltransferase and risk of metabolic syndrome and type 2 diabetes in middle-aged Japanese men" 27 : 1427-1432, 2004

8 Stocker R, "Role of oxidative modifications in atherosclerosis" 84 : 1381-1478, 2004

9 Lafontan M, "Role of adipokines in the control of energy metabolism : focus on adiponectin" 6 : 580-585, 2006

10 Lee MY, "Relationship between gamma-glutamyltransferase and metabolic syndrome in a Korean population" 25 : 469-475, 2008

11 Ndrepepa G, "Relation of gamma-glutamyl transferase to cardiovascular events in patients with acute coronary syndromes" 117 : 1427-1432, 2016

12 Arita Y, "Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity" 257 : 79-83, 1999

13 Otani H, "Oxidative stress as pathogenesis of cardiovascular risk associated with metabolic syndrome" 15 : 1911-1926, 2011

14 Roberts CK, "Oxidative stress and dysregulation of NAD(P)H oxidase and antioxidant enzymes in diet-induced metabolic syndrome" 55 : 928-934, 2006

15 윤연석, "Optimal Waist Circumference Cutoff Values for the Diagnosis of Abdominal Obesity in Korean Adult" 대한내분비학회 29 (29): 418-426, 2014

16 Williams KH, "Opposite associations between alanine aminotransferase and γ-glutamyl transferase levels and all-cause mortality in type 2 diabetes : analysis of the Fenofibrate Intervention and Event Lowering in Diabetes(FIELD)study" 65 : 783-793, 2016

17 Ballestri S, "Nonalcoholic fatty liver disease is associated with an almost twofold increased risk of incident type 2 diabetes and metabolic syndrome. Evidence from a systematic review and meta-analysis" 31 : 936-944, 2016

18 Sookoian S, "NAFLD. Metabolic make-up of NASH: from fat and sugar to amino acids" 11 : 205-207, 2014

19 Alberti KG, "Metabolic syndrome: a new world-wide definition. A Consensus Statement from the International Diabetes Federation" 23 : 469-480, 2006

20 Bonomini F, "Metabolic syndrome, aging and involvement of oxidative stress" 6 : 109-120, 2015

21 Nannipieri M, "Liver enzymes, the metabolic syndrome, and incident diabetes: the Mexico City diabetes study" 28 : 1757-1762, 2005

22 Lim JS, "Is serum gamma-glutamyltransferase inversely associated with serum antioxidants as a marker of oxidative stress?" 37 : 1018-1023, 2004

23 Ferrannini E, "Insulin resistance, insulin response, and obesity as indicators of metabolic risk" 92 : 2885-2892, 2007

24 Cannizzo B, "Insulin resistance promotes early atherosclerosis via increased proinflammatory proteins and oxidative stress in fructose-fed ApoE-KO mice" 2012 : 941304-, 2012

25 Teschke R, "Induction of hepatic microsomal gamma-glutamyltransferase activity following chronic alcohol consumption" 75 : 718-724, 1977

26 Lee DH, "Gamma-glutamyltransferase, obesity, and the risk of type 2 diabetes: observational cohort study among 20,158 middle-aged men and women" 89 : 5410-5414, 2004

27 Liu CF, "Gamma-glutamyltransferase levels and risk of metabolic syndrome : a meta-analysis of prospective cohort studies" 66 : 692-698, 2012

28 Andre P, "Gamma-glutamyltransferase activity and development of the metabolic syndrome (International Diabetes Federation Definition) in middle-aged men and women: data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR) cohort" 30 : 2355-2361, 2007

29 Koenig G, "Gamma-glutamyltransferase : a predictive biomarker of cellular antioxidant inadequacy and disease risk" 2015 : 818570-, 2015

30 Ndrepepa G, "Gamma-glutamyl transferase and cardiovascular disease" 4 : 481-, 2016

31 Kunutsor SK, "Gamma glutamyltransferase and metabolic syndrome risk : a systematic review and dose-response meta-analysis" 69 : 136-144, 2015

32 Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults, "Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)" 285 : 2486-2497, 2001

33 Venturini D, "Evaluation of oxidative stress in overweight subjects with or without metabolic syndrome" 20 : 2361-2366, 2012

34 Thamer C, "Elevated serum GGT concentrations predict reduced insulin sensitivity and increased intrahepatic lipids" 37 : 246-251, 2005

35 American Heart Association, "Diagnosis and management of the metabolic syndrome. An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Executive summary" 13 : 322-327, 2005

36 Kim J, "Development of a food frequency questionnaire in Koreans" 12 : 243-250, 2003

37 Dhananjay Yadav, "Combined Effect of Initial and Longitudinal Increases in γ-Glutamyltransferase on Incident Metabolic Syndrome: ARIRANG Study" 연세대학교의과대학 58 (58): 763-769, 2017

38 Kim Y, "Cohort profile: the Korean Genome and Epidemiology Study (KoGES) consortium" 46 : e20-, 2017

39 Sharpe PC, "Biochemical markers of alcohol abuse" 89 : 137-144, 1996

40 Bo S, "Associations between gamma-glutamyl transferase, metabolic abnormalities and inflammation in healthy subjects from a population-based cohort: a possible implication for oxidative stress" 11 : 7109-7117, 2005

41 Ouchi N, "Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway" 102 : 1296-1301, 2000