이유자돈에 있어 δ - 아미노레불린산의 식이 내 첨가가 성장 및 혈액학적 변화에 미치는 영향

국문 초록 (Abstract)

본 실험은 자돈식이내 δ-아미노레불린산의 첨가가 이유 자돈의 성장능력 및 혈액성상에 미치는 영향을 조사하기 위하여 실시하였다. 사양시험은 3원 교잡종 자돈 75두(평균체중 7.21±0.02 ㎏)를 공시하였다. 시험설계는 1) NC(negative control; 무항생제 기초식이), 2) PC(positive control; NC diet＋0.1% Apramycin＋0.1% Oxytetracycline), 3) ALA0.1(NC diet＋0.1% δ-아미노레불린산), 4) ALA0.2(NC diet＋0.2% δ-아미노레불린산), 5) ALA＋AB (PC diet＋0.2% δ-아미노레불린산)의 5개 처리를 하였다. 총 사양시험기간동안, 일당증체량은 ALA＋AB 처리구가 NC 처리구와 비교하여 유의적으로 높게 평가되었으나(p<0.05), PC, ALA0.1 그리고 ALA0.2 처리구와는 통계적인 차이는 보이지 않았다. 일당식이섭취량과 식이효율에 있어서는 처리구간의 유의적 차이가 없었다. 시험 개시 후 20일령에 측정한 영양소 소화율에 있어서는 건물과 질소 소화율에 있어서 ALA＋AB 처리구가 NC 처리구 및 ALA0.1 처리구와 비교하여 높게 평가되었다(p<0.05). 또한, 혈청내 total protein의 농도에 있어서는 ALA＋AB처리구가 NC 처리구 및 PC 처리구와 비교하여 높게 평가되었다(p<0.05). 혈청내 iron의 농도는 δ-아미노레불린산을 첨가한 처리구가 NC 및 PC 처리구에 비하여 유의적으로 높게 평가되었다(p<0.05). 혈청내 TIBC에 있어서는 ALA＋AB 처리구가 NC, PC 그리고 ALA0.1 처리구와 비교하여 통계적으로 높게 평가되었다(p<0.05). 혈액내 Hb 및 HCT의 농도는 ALA0.2 처리구와 ALA＋AB 처리구가 NC 처리구와 PC 처리구와 비교하여 유의적으로 높게 평가되었다(p<0.05). 혈액내 RBC와 WBC의 농도는 ALA0.2 처리구와 ALA＋AB 처리구가 NC 처리구와 비교하여 유의적으로 높게 평가되었다(p>0.05). 혈액내 lymphocyte는 δ-아미노레불린산 처리구가 NC 처리구와 비교하여 유의적으로 증가하였다(p<0.05). 결론적으로, 자돈식이내 δ-아미노레불린산의 첨가는 자돈의 성장 및 소화율을 향상시키며, 혈액 내 total protein, iron, hemoglobin, lymphocyte의 수준을 증가시켰다. 또한, δ-아미노레불린산과 항생제의 혼합급여는 자돈의 성장 능력에 있어 상승효과를 갖는 것으로 사료된다.

다국어 초록 (Multilingual Abstract)

This study was conducted to investigate the effects of δ-aminolevulinic acid supplementation on growth performance, nutrient digestibility and hematological changes in weaned pigs. Seventy five Duroc×Yorkshire×Landrace pigs (7.21±0.02 ㎏ average BW) were used in a 20 d growth assay. Dietary treatments included 1) NC (negative control; basal diet), 2) PC (positive control; NC diet＋0.1% Apramycin＋0.1% Oxytetracycline), 3) ALA0.1 (NC diet＋0.1% δ-aminolevulinic acid), 4) ALA0.2 (NC diet＋0.2% δ-aminolevulinic acid) and 5) ALA＋AB (PC diet＋0.2% δ-aminolevulinic acid). In entire experimental period, ADG (Average Daily Gain) was greater in pigs fed ALA＋AB diet than in pigs fed NC diet (p<0.05). However, there was no significant difference in ADG for pigs fed PC, ALA0.1 or ALA0.2 diets. Also, ADFI (Average Daily Feed Intake) and G/F (Gain/Feed) were not affected by treatments. For 20 d, fecal digestibilities of DM (Dry Matter) and N (Nitrogen) were higher (p<0.05) for pigs fed ALA＋AB diet than for pigs fed NC and ALA0.1 diets. Total protein concentration of serum was increased in ALA＋AB treatment compared to NC and PC treatments (p<0.05). In iron concentration of serum, pigs fed δ-aminolevulinic acid supplementation diets were greater than for pigs fed NC and PC diets (p<0.05). TIBC (Total Iron Binding Capacity) concentration of serum was increased in ALA＋AB treatment compared to NC, PC and ALA0.1 treatments (p<0.05). Pigs fed ALA＋AB and ALA0.2 diets were higher hemoglobin (Hb) and hematocrit (HCT) concentration of blood than pigs fed NC and PC diets (p<0.05). RBC and WBC concentrations of blood were significantly higher (p<0.05) for the pigs fed ALA0.2 and ALA＋AB diets than for pigs fed NC diet. Lymphocyte concentration of blood was increased in δ-aminolev-ulinic acid supplementation treatment compared to NC treatment (p<0.05). In conclusion, δ-aminolevulinic acid supplementation for weanling pigs had improved growth performance and nutrient digestibilities and had increased total protein, iron, hemoglobin and lymphocyte concentration of blood. Also, feeding for dietary δ-aminolevulinic acid and antibiotic mixture supplementation may have more higher effective growth performance in weanling pigs.

목차 (Table of Contents)

• Abstract
  
• 서론
  
• 재료 및 방법
  
• 결과 및 고찰
  
• 요약
  
• 문헌

참고문헌 (Reference)

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