위 유문동근 K^+ - 경축에 미치는 Vanadate의 효과 = Effects of Vanadate on the K^+-contracture of Guinea-pig's Pyloric Antrum

다국어 초록 (Multilingual Abstract)

Effects of vanadate on the spontaneous contraction and the high K^+-induced contracture of guinea pig’s pyloric antral smooth muscles were observed in the various Na^+ and/or Ca^+ of bathing solutions.
Following results were obtained;
1. Basal tension and developed tension of the spontaneous activity were increased by vanadate and the membrane potential tended to be depolarized.
2. Phasic contracture increased, tonic contracture decreased as the outside K^+ concentration increased and the both components were increased by vanadate.
3. In the case of absence of K^+ and/or Na^+, the contracture were hardly developed and the spontaneous, rhythmic contraction were sustained.
4. Effects of vanadate on the K^+-contracture and the Ca^2+-sensitivity of the Phasit and tonic components were prominent in the presence of Na^+.
The above results suggested that vanadate would increase the voltage-dependent calcium current in smooth muscle cells of the pyloric antrum.