비전형적 림프구성 소엽 지방층염 1예 = Short Report : A Case of Atypical Lymphocytic Lobular Panniculitis

다국어 초록 (Multilingual Abstract)

We report here on a 63-year-old woman who presented with recurrent bruise-like infiltrative plaques on the left leg without systemic symptoms or laboratory abnormalities. The histopathologic findings showed an infiltration of panniculus by small to medium-sized atypical lymphocytes. But the prominent lymphoid atypia, fat necrosis, vascular thrombosis, erythrophagocytosis and striking dominance of CD8＋lymphocytes seen in subcutaneous panniculitis-like T-cell lymphoma (SPTCL) were not detected. The diagnosis of atypical lymphocytic lobular panniculitis (ALLP) was made based on these histopathologic and clinical features. The lesions responded well to systemic steroid treatment. But the CD4/CD8 ratio in the later lesion was more decreased than that of the initial lesion, and the patient is under clinical follow up. (Korean J Dermatol 2010;48(7):637∼641)

참고문헌 (Reference)

1 Magro CM, "The utility of the in situ detection of T-cell receptor beta rearrangements in cutaneous T-cell-dominant infiltrates" 12 : 133-141, 2003

2 Dargent JL, "Subcutaneous lymphoid hyperplasia arising at site of ethnic scarifications and mimicking subcutaneous panniculitis-like T-cell lymphoma:a subcuticular T-cell lymphoid dyscrasia" 444 : 395-396, 2004

3 Dargent JL, "Subcutaneous lymphoid hyperplasia arising at site of ethnic scarifications and mimicking subcutaneous panniculitis-like T-cell lymphoma" 438 : 298-301, 2001

4 Lozzi GP, "Rimming of adipocytes by neoplastic lymphocytes:a histopathologic feature not restricted to subcutaneous T-cell lymphoma" 28 : 9-12, 2006

5 Magro CM, "Lupus profundus,indeterminate lymphocytic lobular panniculitis and subcutaneous T-cell lymphoma:a spectrum of subcuticular T-cell lymphoid dyscrasia" 28 : 235-247, 2001

6 Berlingeri-Ramos AC, "Disease evolution of patients with mycosis fungoides-a report of 30 cases" 26 : 151-154, 2007

7 Ackerman AB, "Decline of a discipline:abetment by journals" 32 : 254-, 2005

8 Guitart J, "Cutaneous T-cell lymphoid dyscrasia:a unifying term for idiopathic chronic dermatoses with persistent T-cell clones" 143 : 921-932, 2007

9 Magro CM, "Atypical lymphocytic lobular panniculitis:a clonal subcutaneous Tcell dyscrasia" 35 : 947-954, 2008

10 Magro CM, "Atypical lymphocytic lobular panniculitis" 31 : 300-306, 2004