병용금기 SCREENING 프로그램 시행 후의 처방 분석 = Prescription Analysis after Operation of Incompatible Drug Screening Program

다국어 초록 (Multilingual Abstract)

On Jan. 16, 2004, the Ministry of Health & Welfare notified the public of ''Incompatible and specified age limits on medications" that were originally selected by the Health Insurance Review Agency as 162 combinations of incompatible drugs and 10 medications whose use is limited by a specified age range. A special program was designed to discriminate 49 incompatible drug combinations that are used in our hospital that has been in operation since May 1, 2004. When incompatible drug combinations are inputted, warning signs appear. The incompatible drug combinations can be prescribed only when a reason for the prescription is inputted. According to sex, age range, inpatient/ outpatient, department, medication and interaction category, we classified and analyzed the prescription cases of incompatible drug combinations made for four months since the program has been implemented in May thru Aug. 2004. For the above-mentioned period, among 203 prescription cases of incompatible drugs, 50% were for above the age of 60 and 90% were for above the age of 40. Among the cases made by various departments, the department of neurology had the highest rate of 79 cases. Among the combinations of incompatible drugs, there were 41 cases of amitriptyline-selegiline, 28 cases of aspirin-MTX, 26 cases of fluconazole- triazolam, 17 cases of itraconazole-triazolam, 14 cases of selegiline-sertraline, 12 cases of itraconazole-simvastatin, 9 cases of amiodarone-lidocaine. Among the indication categories, combination of MAOI and TCA or SSRI was the highest of 70 cases. The representative reasons for the prescription of the incompatible drugs were "Not controllable with other medications", "Low possibility of side effects with a lower dosage" and "Not simultaneous but with time-interval administration". The ratio of incompatible drug prescriptions given out of the entire prescriptions was 0.038% from May to August in 2003 while it was 0.016% from May to August in 2004, which showed a 58% decrease.