산모혈청내 CRP농도가 조기진통억제 예후 판정에 미치는 영향 = The Significance of C-reactive Protein Levels in Maternal Serum with Outcome of Tocolysis

다국어 초록 (Multilingual Abstract)

Subclinical intrauterine infection is an important cause of preterm labor, specifically where tocolysis has failed. So, 57 pregnant women who admitted to Department of Obstetrics and Gynecology of Yeungnam University Hospital during the period through Jan 1988 to Feb 1990 were studied to determine whether the `postive`(CRP>0.7 mg/dl) or `negative`(CRP<0.7 mg/dl) of the C-reactive protein, a marker for subclinical intrauterine infection, would correlated with success or failure of tocolysis. C-reactive protein was serially measured by means of Turbidimetric immunoassay technique every other days. The results were as followed; 1. There were no statistically significant difference in clinical characteristics such as maternal age, parity, abortion, gestational age at admission. 2. C-reactive protein level was significant as an indicator of subclinical intrauterine infection in preterm labor by the comparison of the control group(P<0.01). 3. There were statistically significant differences in mean time from start of labor to delivery and body weight at birth(P<0.05), but no difference in gestational age at delivery, Apgar score, success rate to tocolytic therapy, term or preterm by the C-reactive protein on admission. 4. There were statistically significant differences in mean time from start of labor to delivery and gestational age at delivery, body weight at birth, gestational age at delivery, Apgar score, success rate to tocolytic therapy term or preterm by the C-reactive protein on 2 days after admission(P<0.05, P<0.01, P<0.01, P<0.05, P<0.01, P<0.05). 5. There were statistically significant differences in mean time from start of labor to delivery and success rate to tocolytic therapy, term or preterm(P<0.05, P<0.01, P<0.05), but no difference in gestational age at delivery, body weight at birth, Apgar score by the C-reactive protein on 4 days after admission. C-reactive protein values indicate that it may become possible to predict the sucess or failure of tocolytic therapy in preterm labor by follow up every other days than single CRP measurement. We recommend in cases of preterm labor with high CRP levels or in cases where b sympathomimetic agents fail to stop preterm uterine contraction, that the presence of infection as contributing factor should be suspected, even in the absence of any clinical maniifestation of the infectious process.