Effects of Persimmon-Vinegar on Lipid Metabolism and Alcohol Clearance in Chronic Alcohol-Fed Rats

다국어 초록 (Multilingual Abstract)

The purpose of this study was to investigate the effects of persimmon-vinegar supplementation on lipid pro-files, carnitine levels, and alcohol clearance in chronically alcoholic rats. Sprague-Dawley rats were divided into four groups:the normal control group (NC), the ethanol-administered group (EC) (4 g/kg of body weight), the ethanol plus low-dose per-simmon-vinegar-administered group (EVL) (1 mL/kg of body weight), and the ethanol plus high-dose persimmon-vinegar-administered group (EVH) (2 mL/kg of body weight). In this study, we found that persimmon-vinegar supplementation sig-nificantly decreased serum triglyceride and total cholesterol and liver total cholesterol levels compared to those of the ECgroup. The liver nonesterified carnitine level was significantly elevated in the persimmon-vinegar-administered groups as com-pared to that of the EC group. The blood ethanol concentration tended to be the lowest in the EVH group. There was a trendfor the level of hepatic acetyl-coenzyme A carboxylase mRNA to be decreased and hepatic carnitine palmitoyltransferase-ImRNA to be increased with increasing doses of persimmon-vinegar. These results suggest that supplementation of persim-mon-vinegar prevents metabolic disorders induced by chronic administration of alcohol.

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