만성위염 환자의 유문부 Gastrin 세포의 분포 및 Gastrin 농도 = Antral G - cell Distribution and Gastrin Level in Patients with Chronic Gastritis만성위염 환자의 유문부 Gastrin 세포의 분포 및 Gastrin 농도

다국어 초록 (Multilingual Abstract)

This study was conducted to investigate the influence of chronic gastritis on the distribution of gastrin (G)-cells and gastrin levels in antral mucosa and blood in Korean patients. Fifty-one subjects were divided into three groups according to histological findings of biopsied specimens by endoscopy: normal subjects, patients with chronic superficial gastritis and patients with chronic atrophic gastritis. The G-cells in the antral mucosa were stained by the immunohistochemical method with gastrin antiserum and the number of G-cell per unit area (1 mm breadth of a 5 ㎛-thick sectioned mucosa) was counted. Gastrin levels in the antral mucosal tissue and plasma were measured by means of radioimmunoassay. The results were as follows: 1) The number of G-cells and the antral tissue gastrin level in normal subjects were 106±36.6 and 10.6±6.2㎍/g, respectively. Plasma gastrin concentrations of the normal subjects in fasting and postprandial states, 20 min and 40 min after ingestion of a meat meal, were 63.1±24.5, 141.8±73.8 and 126.0±62.5 pg/ml, respectively. 2) In patients with chronic superficial gastritis, fasting and postprandial plasma gastrin concentrations increased significantly compared with those of the normal subjects, while the number of the G-cells and antral tissue gastrin were not significantly different from the normal values. 3) In patients with chronic atrophic gastritis, the number of G-cells and antral tissue gastrin levels tended to decrease, but fasting and postprandial plasma gastrin concentrations tended to increase compared with the normal values. 4) No G-cells were observed in the region with intestinal metaplasia. The above results indicate that patients with chronic gastritis showed a marked increase in plasma gastrin concentration while the number of antral G-cells and antral tissue gastrin level decreased.