검정콩 안토시아닌의 마우스를 이용한 안전성 연구 = Evaluation of Toxicity of Anthocyanin from Black Soybean by Feeding Test in Mice

다국어 초록 (Multilingual Abstract)

Over the past few years, anthocyanin has been demonstrated to exert potentially anti-oxidative and bioavailability effects
including anti-cardiovascular disease and cancer-preventive effects in humans. This study was conducted to assess the toxicity
of anthocyanin extracts from black soybean seed coats via oral administration in a mice feeding test. The final anthocyanincontaining
products induced signs of toxicity on mortality in the 4-week feeding test. The incidence of clinical signs and
changes in body and organ weight were also not observed in all anthocyanin-treated groups as compared with the control
groups. In hematology analysis, RBC indices concluding MCV, MCH, and MCHC and WBC differential counting such a
NEU, LYM, MONO, EOS, and BASO evidenced no significant differences between the anthocyanin treatment and control
groups. The biochemical parameters in serum analysis - ALT, AST, BUN, Crea etc.- were also not significantly altered
in those groups. Absolute and relative organ weights were not increased after 4 weeks of treatment with anthocyanin extracts
in mice. In conclusion, anthocyanin extracts from the black soybean has biological activity without any toxic effects, which
also suggests that the consumption of soy containing anthocyanin products may be a good source for health and medical
supplies.

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