Surface, thermodynamic and biological activities of some synthesized Gemini quaternary ammonium salts based on polyethylene glycol

다국어 초록 (Multilingual Abstract)

Quaternary ammonium salts are frequently used as antimicrobial agents that disrupt cell membranethrough the binding of their ammonium cations to anionic sites in the outer tissue of bacteria. This articledescribes the synthesis of Gemini quaternary ammonium salts (G600Br, G1000Br and G1500Br). Thechemical structures of synthesized Gemini quaternary ammonium salts were confirmed using FT-IR and1HNMR spectra. The surface activity of the synthesized surfactants were determined from the surfaceand interfacial tension measurements. The surface parameter including: the critical micelleconcentration (CMC), effectiveness (pcmc), efficiency (Pc20), maximum surface excess (Gmax) andminimum surface area (Amin), were calculated from the surface tension measurements, also, the foamingand emulsification power were measured. The thermodynamic parameters of micellization andadsorption showed their tendency towards adsorption at the interfaces and also micellization in the bulkof their solutions. Screening tests of the synthesized compounds showed that the compounds exhibit aneffective antimicrobial activity on a variety of bacteria including Gram-positive bacteria (Bacillus subtilisand Micrococcus luteus), Gram-negative bacteria (Bordetella pertussis and Escherichia coli) and Fungi(Candida albicans and Aspergillus niger).

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