RISS 검색 - 국내학술지논문 상세보기

다국어 초록 (Multilingual Abstract)

Background: Psoriasis is a chronic inflammatory skin disorder histopathologically characterized by epidermal hyperplasia, vascular proliferation, and inflammatory infiltrates. It runs a less severe course in women than in men. The role of estrogen in the pathogenesis of psoriasis remains unclear.
Objective: We investigated the clinicohistopathological differences between men and women with psoriasis and examined whether serum estrogen levels and immunohistochemical findings correlate with gender and disease severity.
Methods: We retrospectively reviewed the medical records of 500 patients with psoriasis. Among these patients, 60 who consented to participate in the study were classified into four groups as follows: 10 men showing psoriasis on ＜10% of their body surface area (BSA) with psoriasis area severity index (PASI)＜10; 20 men showing psoriasis on ≥10% of their BSA with PASI≥10; 10 women showing psoriasis on ＜10% of their BSA with PASI＜10; and 20 women showing psoriasis on ≥10% of their BSA with PASI ≥10. Serum estrogen levels were measured using radioimmunoassay. Immunohistochemical staining of skin biopsy tissues was performed using ERα, ERβ, and CCL5.
Results: Men diagnosed with psoriasis showed higher BSA and PASI scores than women. Women aged ≥60 years showed higher BSA and PASI scores than women aged ＜60 years. There were no histological differences between the four groups. Serum estrogen levels were higher in the patients presenting with mild psoriasis, as well as in women. ERα, ERβ, and CCL5 showed a stronger staining tendency in patients with more severe psoriasis.
Conclusion: Gender influences the severity of psoriasis, and estrogen plays an important role. This finding is explained by the fact that estrogen decreases inflammation in psoriasis possibly via its action on estrogen receptors in epidermal keratinocytes. (Korean J Dermatol 2017;55(9):565∼571)

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참고문헌 (Reference)

1 Raychaudhuri SP, "Upregulation of RANTES in psoriatic keratinocytes:a possible pathogenic mechanism for psoriasis" 79 : 9-11, 1999

2 Hodak E, "The insulin-like growth factor 1 receptor is expressed by epithelial cells with proliferative potential in human epidermis and skin appendages: correlation of increased expression with epidermal hyperplasia" 106 : 564-570, 1996

3 Danesh M, "The immunologic effects of estrogen on psoriasis: a comprehensive review" 1 : 104-107, 2015

4 Hägg D, "The higher proportion of men with psoriasis treated with biologics may be explained by more severe disease in men" 8 : e63619-, 2013

5 Thornton MJ, "The distribution of estrogen receptor beta is distinct to that of estrogen receptor alpha and the androgen receptor in human skin and the pilosebaceous unit" 8 : 100-103, 2003

6 Hotard RS, "Sex-specific differences in the treatment of severe psoriasis" 42 : 620-623, 2000

7 Cemil BC, "Sex hormones in male psoriasis patients and their correlation with the Psoriasis Area and Severity Index" 42 : 500-503, 2015

8 Hägg D, "Severity of psoriasis differs between men and women: a study of the clinical outcome measure psoriasis area and severity index (PASI) in 5438 Swedish register patients" 2017

9 Wraight CJ, "Reversal of epidermal hyperproliferation in psoriasis by insulin-like growth factor I receptor antisense oligonucleotides" 18 : 521-526, 2000

10 Rateb AA, "Reduction of RANTES expression in lesional psoriatic skin after narrow band ultraviolet therapy: a possible marker of therapeutic efficacy" 22 : 481-487, 2012